Photo-targeted nanoparticles

Tal Dvir, Matthew R. Banghart, Brian P. Timko, Robert Langer, Daniel S. Kohane

Research output: Contribution to journalArticlepeer-review

120 Scopus citations

Abstract

We report a novel and simple proof-of-concept of a nanoparticulate system that targets any tissue selectively upon illumination. Nanoparticles were covalently functionalized with the amino acid sequence YIGSR, which adheres to the β1 integrins present on most cell surfaces. This peptide was masked with a caging group, rendering it biologically inert. Illumination with UV light released the caging group from the YIGSR, allowing binding to cells.

Original languageEnglish
Pages (from-to)250-254
Number of pages5
JournalNano Letters
Volume10
Issue number1
DOIs
StatePublished - 13 Jan 2010
Externally publishedYes

Funding

FundersFunder number
National Institute of General Medical SciencesR01GM073626

    Keywords

    • Caging group
    • Cell targeting
    • Drug delivery
    • Light
    • Nanoparticles

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