Phospholipid peroxidation as a factor in gallstone pathogenesis

D. Lichtenberg, S. Ragimova, Y. Peled, Z. Halpern

Research output: Contribution to journalArticlepeer-review

Abstract

Phospholipid peroxidation markedly reduces the stability of mixed micellar systems composed of cholate, phosphatidylcholine and supersaturating levels of cholesterol. This suggests that lipid peroxidation is likely to play a significant role in the precipitation of cholesterol from gallbladder bile, thus in the pathogenesis of cholesterol gallstones. This conclusion is supported by studies of the nucleation time of cholesterol in gallbladder biles, which was significantly reduced by exposure to a stream of oxygen. This effect of phospholipid peroxidation on cholesterol solubility may occur in other biological fluids as well. In view of the increased lipid peroxidation in the elderly, it may explain the effect of age on the frequency of various diseases related to cholesterol precipitation.

Original languageEnglish
Pages (from-to)179-181
Number of pages3
JournalFEBS Letters
Volume228
Issue number1
DOIs
StatePublished - 8 Feb 1988

Keywords

  • Cholesterol precipitation
  • Gallstone
  • Lipid peroxidation

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