@article{b1e0385657f841ea9160ea615cc8b503,
title = "Phosphoinositide breakdown in isolated rat parotid membranes. Stimulation by cholinergic and α-adrenergic agonists",
abstract = "Parotid gland membranes labelled with [3H]inositol were challenged with the cholinergic agonist, carbamylcholine, or with epinephrine in the presence of propranolol. Both agonists caused a significant breakdown of labelled phosphoinositides (17.5%) in membranes suspended in Krebs-Ringer bicarbonate buffer. This effect was abolished by the respective antagonists, atropine or phentolamine. The carbamylcholine-induced breakdown of labelled phosphoinositides did not require cytosol. The addition of cytosol alone, or the exposure of membranes to a medium of low ionic strength caused a significant breakdown of phosphoinositides (10-40%). No further breakdown due to the addition of carbamylcholine was observed under these conditions. It is suggested that neurotransmitter-induced breakdown of phosphoinositides is effected by membrane-associated enzyme(s) and can be observed only in a medium of high ionic strength.",
keywords = "Cholinergic receptor, Parotid membrane, Phosphoinositide breakdown",
author = "E. Nadler and Nijjar, {M. S.} and Y. Oron",
note = "Funding Information: This researchw ass upportedb y grantsf rom The SchreiberF oundation, The Recanati Foundation for Medical Researcha nd the Tel Aviv University Fund for Basic Research.",
year = "1984",
month = dec,
day = "10",
doi = "10.1016/0014-5793(84)80616-X",
language = "אנגלית",
volume = "178",
pages = "278--282",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "John Wiley and Sons Inc.",
number = "2",
}