Pheochromocytoma: An animal model

V. Burroughs, M. Goldstein, L. Shenkman

Research output: Contribution to journalArticlepeer-review


A reproducible animal model for studying pheochromocytoma is described. Rat pheochromocytoma cells (PC-12 line) maintained in tissue culture and injected subcutaneously into rats produce a functioning tumor at the site of inoculation. Animals harboring these tumors develop alterations characteristic of pheochromocytoma including weight loss, hypertension and a contracted blood volume. This model provides an easily reproducible system for studying the pathophysiologic features of pheochromocytoma.

Original languageEnglish
Pages (from-to)174-179
Number of pages6
JournalHormone Research
Issue number3
StatePublished - 1980
Externally publishedYes


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