Pheochromocytoma: An animal model

V. Burroughs; M. Goldstein; L. Shenkman

doi:10.1159/000179284

Pheochromocytoma: An animal model

V. Burroughs, M. Goldstein, L. Shenkman

Research output: Contribution to journal › Article › peer-review

Abstract

A reproducible animal model for studying pheochromocytoma is described. Rat pheochromocytoma cells (PC-12 line) maintained in tissue culture and injected subcutaneously into rats produce a functioning tumor at the site of inoculation. Animals harboring these tumors develop alterations characteristic of pheochromocytoma including weight loss, hypertension and a contracted blood volume. This model provides an easily reproducible system for studying the pathophysiologic features of pheochromocytoma.

Original language	English
Pages (from-to)	174-179
Number of pages	6
Journal	Hormone Research
Volume	13
Issue number	3
DOIs	https://doi.org/10.1159/000179284
State	Published - 1980
Externally published	Yes

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10.1159/000179284

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title = "Pheochromocytoma: An animal model",

abstract = "A reproducible animal model for studying pheochromocytoma is described. Rat pheochromocytoma cells (PC-12 line) maintained in tissue culture and injected subcutaneously into rats produce a functioning tumor at the site of inoculation. Animals harboring these tumors develop alterations characteristic of pheochromocytoma including weight loss, hypertension and a contracted blood volume. This model provides an easily reproducible system for studying the pathophysiologic features of pheochromocytoma.",

author = "V. Burroughs and M. Goldstein and L. Shenkman",

year = "1980",

doi = "10.1159/000179284",

language = "אנגלית",

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AU - Goldstein, M.

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AB - A reproducible animal model for studying pheochromocytoma is described. Rat pheochromocytoma cells (PC-12 line) maintained in tissue culture and injected subcutaneously into rats produce a functioning tumor at the site of inoculation. Animals harboring these tumors develop alterations characteristic of pheochromocytoma including weight loss, hypertension and a contracted blood volume. This model provides an easily reproducible system for studying the pathophysiologic features of pheochromocytoma.

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JO - Hormone Research in Paediatrics

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SN - 1663-2818

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Pheochromocytoma: An animal model

Abstract

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