Phenytoin Intoxication in a Clozapine-Related Prolonged Seizure

Revital Gandelman-Marton; Jacques Theitler; Colin Klein; Jose Martin Rabey

doi:10.1016/j.jemermed.2007.06.012

Phenytoin Intoxication in a Clozapine-Related Prolonged Seizure

Revital Gandelman-Marton^*, Jacques Theitler, Colin Klein, Jose Martin Rabey

^*Corresponding author for this work

Clinical Departments

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Phenytoin is a first-line drug for the treatment of status epilepticus. We report a case of phenytoin intoxication after intravenous phenytoin loading in a patient with clozapine-related seizures. To our knowledge, this is the first description of phenytoin intoxication due to CYP2C9 inhibition by clozapine. This case report is important because it supports the use of a lower intravenous loading dose of phenytoin in patients with clozapine-related status epilepticus.

Original language	English
Pages (from-to)	407-409
Number of pages	3
Journal	Journal of Emergency Medicine
Volume	35
Issue number	4
DOIs	https://doi.org/10.1016/j.jemermed.2007.06.012
State	Published - Nov 2008

Keywords

clozapine
cytochrome P450
phenytoin
seizure

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10.1016/j.jemermed.2007.06.012

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abstract = "Phenytoin is a first-line drug for the treatment of status epilepticus. We report a case of phenytoin intoxication after intravenous phenytoin loading in a patient with clozapine-related seizures. To our knowledge, this is the first description of phenytoin intoxication due to CYP2C9 inhibition by clozapine. This case report is important because it supports the use of a lower intravenous loading dose of phenytoin in patients with clozapine-related status epilepticus.",

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AB - Phenytoin is a first-line drug for the treatment of status epilepticus. We report a case of phenytoin intoxication after intravenous phenytoin loading in a patient with clozapine-related seizures. To our knowledge, this is the first description of phenytoin intoxication due to CYP2C9 inhibition by clozapine. This case report is important because it supports the use of a lower intravenous loading dose of phenytoin in patients with clozapine-related status epilepticus.

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Phenytoin Intoxication in a Clozapine-Related Prolonged Seizure

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Keywords

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