Phenytoin and folate deficiency: Failure to show dose dependency

Amos D. Korczyn; Marta Elian; Ruth Don; B. Bornstein

doi:10.1007/BF00594091

Phenytoin and folate deficiency: Failure to show dose dependency

Amos D. Korczyn^*, Marta Elian, Ruth Don, B. Bornstein

^*Corresponding author for this work

Physiology Pharmacology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Blood folic acid levels of 44 epileptic patients being treated with phenytoin were evaluated. Many patients had lowered FA levels but no significant correlation could be shown between the daily dosage of the drug and the vitamin level in the blood. It would therefore seem that the depression of folic acid levels in patients on anticonvulsants depends on individual factors and perhaps duration of treatment rather than being a toxic, dose-dependent response.

Original language	English
Pages (from-to)	151-153
Number of pages	3
Journal	Journal of Neurology
Volume	207
Issue number	2
DOIs	https://doi.org/10.1007/BF00594091
State	Published - Jun 1974

Keywords

Anticonvulsants
Epilepsy
Folic acid
Phenytoin

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10.1007/BF00594091

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abstract = "Blood folic acid levels of 44 epileptic patients being treated with phenytoin were evaluated. Many patients had lowered FA levels but no significant correlation could be shown between the daily dosage of the drug and the vitamin level in the blood. It would therefore seem that the depression of folic acid levels in patients on anticonvulsants depends on individual factors and perhaps duration of treatment rather than being a toxic, dose-dependent response.",

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author = "Korczyn, {Amos D.} and Marta Elian and Ruth Don and B. Bornstein",

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AB - Blood folic acid levels of 44 epileptic patients being treated with phenytoin were evaluated. Many patients had lowered FA levels but no significant correlation could be shown between the daily dosage of the drug and the vitamin level in the blood. It would therefore seem that the depression of folic acid levels in patients on anticonvulsants depends on individual factors and perhaps duration of treatment rather than being a toxic, dose-dependent response.

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Phenytoin and folate deficiency: Failure to show dose dependency

Abstract

Keywords

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