Phenytoin and folate deficiency: Failure to show dose dependency

Amos D. Korczyn*, Marta Elian, Ruth Don, B. Bornstein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Blood folic acid levels of 44 epileptic patients being treated with phenytoin were evaluated. Many patients had lowered FA levels but no significant correlation could be shown between the daily dosage of the drug and the vitamin level in the blood. It would therefore seem that the depression of folic acid levels in patients on anticonvulsants depends on individual factors and perhaps duration of treatment rather than being a toxic, dose-dependent response.

Original languageEnglish
Pages (from-to)151-153
Number of pages3
JournalJournal of Neurology
Issue number2
StatePublished - Jun 1974


  • Anticonvulsants
  • Epilepsy
  • Folic acid
  • Phenytoin


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