@article{3bb9c6d4e03347a78e14d87c360fb9de,
title = "Phenotypic diversity and plasticity in circulating neutrophil subpopulations in cancer",
abstract = "Controversy surrounds neutrophil function in cancer because neutrophils were shown to provide both pro- and antitumor functions. We identified a heterogeneous subset of low-density neutrophils (LDNs) that appear transiently in self-resolving inflammation but accumulate continuously with cancer progression. LDNs display impaired neutrophil function and immunosuppressive properties, characteristics that are in stark contrast to those of mature, high-density neutrophils (HDNs). LDNs consist of both immature myeloid-derived suppressor cells (MDSCs) and mature cells that are derived from HDNs in a TGF-β-dependent mechanism. Our findings identify three distinct populations of circulating neutrophils and challenge the concept that mature neutrophils have limited plasticity. Furthermore, our findings provide a mechanistic explanation to mitigate the controversy surrounding neutrophil function in cancer.",
author = "Sagiv, {Jitka Y.} and Janna Michaeli and Simaan Assi and Inbal Mishalian and Hen Kisos and Liran Levy and Pazzit Damti and Delphine Lumbroso and Lola Polyansky and Sionov, {Ronit V.} and Amiram Ariel and Hovav, {Avi Hai} and Erik Henke and Fridlender, {Zvi G.} and Zvi Granot",
note = "Publisher Copyright: {\textcopyright} 2015 The Authors.",
year = "2015",
month = feb,
day = "3",
doi = "10.1016/j.celrep.2014.12.039",
language = "אנגלית",
volume = "10",
pages = "562--573",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "4",
}
