@article{d57928cd66d144fbbc5e5625db92e569,
title = "PHB3 Maintains Root Stem Cell Niche Identity through ROS-Responsive AP2/ERF Transcription Factors in Arabidopsis",
abstract = "The root stem cell niche, which is composed of four mitotically inactive quiescent center (QC) cells and the surrounding actively divided stem cells in Arabidopsis, is critical for growth and root development. Here, we demonstrate that the Arabidopsis prohibitin protein PHB3 is required for the maintenance of root stem cell niche identity by both inhibiting proliferative processes in the QC and stimulating cell division in the proximal meristem (PM). PHB3 coordinates cell division and differentiation in the root apical meristem by restricting the spatial expression of ethylene response factor (ERF) transcription factors 115, 114, and 109. ERF115, ERF114, and ERF109 mediate ROS signaling, in a PLT-independent manner, to control root stem cell niche maintenance and root growth through phytosulfokine (PSK) peptide hormones in Arabidopsis. Prohibitins (PHBs) have been identified as negative regulators of the cell cycle. Here, Kong et al. demonstrate that Arabidopsis PHB3 is essential to maintain QC and DSC identity, and it controls root meristem activity by restricting the spatial expression of the ROS-responsive factors ERF115, 114, and 109 in root.",
keywords = "ERF, PSK, ROS, prohibitin 3, root, stem cell niche",
author = "Xiangpei Kong and Huiyu Tian and Qianqian Yu and Feng Zhang and Rong Wang and Shan Gao and Wenhong Xu and Jiajia Liu and Eilon Shani and Chunxiang Fu and Gongke Zhou and Liangran Zhang and Xiansheng Zhang and Zhaojun Ding",
note = "Publisher Copyright: {\textcopyright} 2017 The Author(s)",
year = "2018",
month = jan,
day = "30",
doi = "10.1016/j.celrep.2017.12.105",
language = "אנגלית",
volume = "22",
pages = "1350--1363",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "5",
}