TY - JOUR
T1 - Phase I and pharmacokinetic study of KRN8602 alone and with filgrastim in patients with advanced cancer
AU - Clarke, Kerrie
AU - Basser, Russell L.
AU - Maher, Darryl
AU - Morgan, Denis J.
AU - Cebon, Jonathan
AU - Fox, Richard M.
AU - Hill, John S.
AU - Alt, Carole
AU - Bartlett, Jane
AU - Geldard, Howard
AU - Kaye, Andrew H.
AU - Green, Michael D.
PY - 1998/6
Y1 - 1998/6
N2 - Purpose: To determine the recommended dose, toxicity profile, and pharmacokinetics of KRN8602 (MX2-hydrochloride), a novel morpholino anthracycline with potent cytotoxicity against anthracycline-sensitive and resistant experimental tumors in vitro and in viva. Patients and Methods: KRN8602 was administered alone in increasing closes to patients with advanced cancer or high-grade gliomas until dose-limiting toxicity (DLT) was observed in three or more of five patients treated in a dose level. Because neutropenia was dose limiting, further escalation was investigated with filgrastim support. Results: Fifty-six assessable patients completed at least one cycle of chemotherapy. The recommended dose of KRN8602 alone was 40 mg/m2. Dose escalation was limited by neutropenia. The recommended dose of KRN8602 with filgrastim was 70 mg/m2, and limiting toxicities were neutropenia, diarrhea, and vomiting. The most commonly experienced nonhematologic toxicity was nausea and vomiting. Alopecia and mucositis were infrequent and mild. Pharmacokinetic parameters showed substantial variation, although the area under the plasma concentration-time curve (AUC) and maximum concentration both increased with dose. There was no relationship between pharmacokinetic parameters and toxicity. Conclusion: KRN8602 at doses of 40 mg/m2 when administered alone and 70 mg/m2 when administered with filgrastim appeared to be manageable. The major DLTs were neutropenia and, at higher doses, diarrhea and vomiting. The efficacy of this drug is currently being tested in phase II studies.
AB - Purpose: To determine the recommended dose, toxicity profile, and pharmacokinetics of KRN8602 (MX2-hydrochloride), a novel morpholino anthracycline with potent cytotoxicity against anthracycline-sensitive and resistant experimental tumors in vitro and in viva. Patients and Methods: KRN8602 was administered alone in increasing closes to patients with advanced cancer or high-grade gliomas until dose-limiting toxicity (DLT) was observed in three or more of five patients treated in a dose level. Because neutropenia was dose limiting, further escalation was investigated with filgrastim support. Results: Fifty-six assessable patients completed at least one cycle of chemotherapy. The recommended dose of KRN8602 alone was 40 mg/m2. Dose escalation was limited by neutropenia. The recommended dose of KRN8602 with filgrastim was 70 mg/m2, and limiting toxicities were neutropenia, diarrhea, and vomiting. The most commonly experienced nonhematologic toxicity was nausea and vomiting. Alopecia and mucositis were infrequent and mild. Pharmacokinetic parameters showed substantial variation, although the area under the plasma concentration-time curve (AUC) and maximum concentration both increased with dose. There was no relationship between pharmacokinetic parameters and toxicity. Conclusion: KRN8602 at doses of 40 mg/m2 when administered alone and 70 mg/m2 when administered with filgrastim appeared to be manageable. The major DLTs were neutropenia and, at higher doses, diarrhea and vomiting. The efficacy of this drug is currently being tested in phase II studies.
UR - http://www.scopus.com/inward/record.url?scp=0031749735&partnerID=8YFLogxK
U2 - 10.1200/JCO.1998.16.6.2181
DO - 10.1200/JCO.1998.16.6.2181
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AN - SCOPUS:0031749735
SN - 0732-183X
VL - 16
SP - 2181
EP - 2187
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 6
ER -
