Pharmacological treatment of laser eye injuries by neuroprotection

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Many retinal injuries result in an irreversible neuronal loss, which can not yet be reduced by pharmacological methods. To determine whether glutamate-receptor blockers can serve as neuroprotective agents in the retina, as they do in the central nervous system, we examined the effects of MK-801, an NMDA-receptor antagonist, on laser-induced retinal injury in a rat model. Immediately and 8 h after argon laser retinal photocoagulation, rats were treated with intraperitoneal injections of MK-801 (3 mg/kg) or saline. After 3, 20 or 60 days the animals were sacrificed and their retinal lesions were evaluated histologically and morphometrically. Photoreceptor cell loss, both immediately and up to 2 months after laser irradiation, was significantly smaller in MK-801-treated rats than controls. MK-801 exhibits neuroprotective property in the retina. This points to the involvement of glutamate in the laser-induced retinal neuronal damage. Glutamate-receptor blockers should be further investigated for therapy of retinal diseases characterized by neuronal cell destruction.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsBruce E. Stuck, Michael Belkin
Pages175-182
Number of pages8
StatePublished - 1996
EventLaser-Inflicted Eye Injuries: Epidemiology, Prevention, and Treatment - San Jose, CA, USA
Duration: 29 Jan 199630 Jan 1996

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume2674
ISSN (Print)0277-786X

Conference

ConferenceLaser-Inflicted Eye Injuries: Epidemiology, Prevention, and Treatment
CitySan Jose, CA, USA
Period29/01/9630/01/96

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