Pharmacokinetics of two dosage regimens of ciprofloxacin during a two-week therapeutic trial in patients with cystic fibrosis

H. R. Stutman, I. Shalit, M. I. Marks, R. Greenwood, S. A. Chartrand, B. C. Hilman

Research output: Contribution to journalArticlepeer-review

Abstract

Twenty-nine adult patients with cystic fibrosis received 750 or 1,000 mg of ciprofloxacin orally every 12 hours for two weeks. Pharmacokinetic data were collected on Days 1, 7, and 14. Pharmacokinetic analyses revealed minor differences between the dosage regimens, and results were similar on the first, seventh, and last day of therapy. Means for peak serum concentration (3.1 to 5.0 μg/ml), elimination half-life (4.8 to 5.3 hours), area under the time-concentration curve, and serum clearance (36.8 to 44.5 liter/hour) were similar to previously reported results for patients without cystic fibrosis. Sputum concentrations approximated serum values.

Original languageEnglish
Pages (from-to)142-145
Number of pages4
JournalAmerican Journal of Medicine
Volume82
Issue number4 A
StatePublished - 1987
Externally publishedYes

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