Pharmacokinetics of methotrexate after local tubal injection for conservative treatment of ectopic pregnancy

E. Schiff; E. Shalev; M. Bustan; A. Tsabari; S. Mashiach; E. Weiner

doi:10.1016/S0015-0282(16)54923-1

Pharmacokinetics of methotrexate after local tubal injection for conservative treatment of ectopic pregnancy

E. Schiff
, E. Shalev^*
, M. Bustan
, A. Tsabari
, S. Mashiach
, E. Weiner

^*Corresponding author for this work

Emek Medical Center

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Methotrexate peak level after intratubal injection was found to be significantly lower than the accepted toxic level. After IM injection, MTX peak level and the AUC were found to be similar to the levels observed after intratubal injection. The advantage of tubal injection over IM injection is challenged.

Original language	English
Pages (from-to)	688-690
Number of pages	3
Journal	Fertility and Sterility
Volume	57
Issue number	3
DOIs	https://doi.org/10.1016/S0015-0282(16)54923-1
State	Published - 1992
Externally published	Yes

Keywords

Ectopic pregnancy
methotrexate pharmacokinetics

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10.1016/S0015-0282(16)54923-1

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title = "Pharmacokinetics of methotrexate after local tubal injection for conservative treatment of ectopic pregnancy",

abstract = "Methotrexate peak level after intratubal injection was found to be significantly lower than the accepted toxic level. After IM injection, MTX peak level and the AUC were found to be similar to the levels observed after intratubal injection. The advantage of tubal injection over IM injection is challenged.",

keywords = "Ectopic pregnancy, methotrexate pharmacokinetics",

author = "E. Schiff and E. Shalev and M. Bustan and A. Tsabari and S. Mashiach and E. Weiner",

year = "1992",

doi = "10.1016/S0015-0282(16)54923-1",

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AU - Schiff, E.

AU - Shalev, E.

AU - Bustan, M.

AU - Tsabari, A.

AU - Mashiach, S.

AU - Weiner, E.

PY - 1992

Y1 - 1992

N2 - Methotrexate peak level after intratubal injection was found to be significantly lower than the accepted toxic level. After IM injection, MTX peak level and the AUC were found to be similar to the levels observed after intratubal injection. The advantage of tubal injection over IM injection is challenged.

AB - Methotrexate peak level after intratubal injection was found to be significantly lower than the accepted toxic level. After IM injection, MTX peak level and the AUC were found to be similar to the levels observed after intratubal injection. The advantage of tubal injection over IM injection is challenged.

KW - Ectopic pregnancy

KW - methotrexate pharmacokinetics

UR - https://www.scopus.com/pages/publications/0026576027

U2 - 10.1016/S0015-0282(16)54923-1

DO - 10.1016/S0015-0282(16)54923-1

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AN - SCOPUS:0026576027

SN - 0015-0282

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SP - 688

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JO - Fertility and Sterility

JF - Fertility and Sterility

IS - 3

ER -

Pharmacokinetics of methotrexate after local tubal injection for conservative treatment of ectopic pregnancy

Abstract

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