Pharmacokinetics of methotrexate after local tubal injection for conservative treatment of ectopic pregnancy

E. Schiff, E. Shalev, M. Bustan, A. Tsabari, S. Mashiach, E. Weiner

Research output: Contribution to journalArticlepeer-review

Abstract

Methotrexate peak level after intratubal injection was found to be significantly lower than the accepted toxic level. After IM injection, MTX peak level and the AUC were found to be similar to the levels observed after intratubal injection. The advantage of tubal injection over IM injection is challenged.

Original languageEnglish
Pages (from-to)688-690
Number of pages3
JournalFertility and Sterility
Volume57
Issue number3
DOIs
StatePublished - 1992
Externally publishedYes

Keywords

  • Ectopic pregnancy
  • methotrexate pharmacokinetics

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