Pharmacogenomics: The importance of accurate phenotypes

David Gurwitz, Munir Pirmohamed

Research output: Contribution to journalReview articlepeer-review

Abstract

Lack of knowledge regarding genotype-phenotype correlations is often cited as the major barrier delaying the uptake of pharmacogenomics into routine medical practice. When we look forward to genome-wide association studies as one of the most promising tools for overcoming the pharmacogenomics knowledge barrier, we must keep in mind that having large patient cohorts may not help improve our understanding of alleles implicated in drug-response phenotypes, unless we ensure that such phenotypes are precise and pertinent. It may be wiser, and far more cost effective, to invest scarce research funding in accurate patient drug-response phenotyping than to genotype (or fully sequence) hundreds to thousands of study participants. Biobanks created with personalized medicine research in mind should, when possible, have access to donors clinical data, including detailed disease-and drug-response phenotypes.

Original languageEnglish
Pages (from-to)469-470
Number of pages2
JournalPharmacogenomics
Volume11
Issue number4
DOIs
StatePublished - Apr 2010

Keywords

  • Adverse drug reactions
  • Biobanks
  • Drug efficacy
  • Drug-response phenotype
  • Electronic health records
  • Epigenomics
  • Pharmacogenetics
  • Pharmacogenomics

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