Pharmaceutical Transformation Products Formed by Ozonation—Does Degradation Occur?

Adi Zilberman, Igal Gozlan, Dror Avisar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The efficiency of an advanced oxidation process (AOP) using direct and indirect ozonation for the removal of pharmaceutical residues from deliberately spiked deionized water was examined. Both direct and indirect ozonation demonstrated 34% to 100% removal of the parent compounds. However, based on the products’ chemical structure and toxicity, we suggest that despite using accepted and affordable ozone and radical concentrations, the six parent compounds were not fully degraded, but merely transformed into 25 new intermediate products. The transformation products (TPs) differed slightly in structure but were mostly similar to their parent compounds in their persistence, stability and toxicity; a few of the TPs were found to be even more toxic than their parent compounds. Therefore, an additional treatment is required to improve and upgrade the traditional AOP toward degradation and removal of both parent compounds and their TPs for safer release into the environment.

Original languageEnglish
Article number1227
Issue number3
StatePublished - Feb 2023


  • degradation
  • ozonation
  • persistent compound
  • pharmaceutical
  • transformation product


Dive into the research topics of 'Pharmaceutical Transformation Products Formed by Ozonation—Does Degradation Occur?'. Together they form a unique fingerprint.

Cite this