pH-Responsive single walled carbon nanotube dispersion for target specific release of doxorubicin to cancer cells

Moumita Ghosh, Sayanti Brahmachari, Prasanta Kumar Das

Research output: Contribution to journalArticlepeer-review

Abstract

Cholesterol-based dipeptide carboxylates were synthesized and exploited for the pH responsive reversible dispersion and precipitation of single walled carbon nanotube (SWCNT) in water specifically at tumorogenic environmental pH (6.0-6.5). The nanohybrid showed excellent pH responsive drug release between pH range of 6.0 and 6.5. The exfoliation of SWCNTs was characterized by microscopic and spectroscopic studies. Importantly, drugloaded SWCNT dispersions showed better killing efficiency compared to that of the native drug and were highly efficient in selective killing of cancer cells (Hela, HepG2) with 2.5-fold higher efficacy compared to that of normal cells (CHO, NIH3T3).

Original languageEnglish
Pages (from-to)1795-1806
Number of pages12
JournalMacromolecular Bioscience
Volume14
Issue number12
DOIs
StatePublished - Dec 2014
Externally publishedYes

Keywords

  • Dispersion
  • Doxorubicin
  • Single walled carbon nanotubes (SWCNTs)
  • Target specific killing
  • pH responsive

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