pH-Induced Platelet Ultrastructural Alterations: A Possible Mechanism for Impaired Platelet Aggregation

Meir Djaldetti, Pnina Fishman, Hanna Bessler, Chaim Chaimoff

Research output: Contribution to journalArticlepeer-review

Abstract

After the observation that lavages with alkaline solutions exert a beneficial effect on the bleeding tendency and increase platelet aggregation in patients with intragastric hemorrhage, studies were undertaken to find a relationship between changes of pH and platelet morphology. Transmission and scanning electron microscopy showed that at a pH lower than 7.4, normal human platelets change their internal structure as well as their shape, becoming spheres deprived of pseudopodia. On the other hand, a pH higher than 7.4 induces transformation of platelet internal organelles similar to that caused by thrombin. At an alkaline pH, the platelets develop multiple pseudopodia that facilitate their attachment to each other. These findings may explain the increased platelet aggregation in alkaline medium demonstrated in one of our previous works.

Original languageEnglish
Pages (from-to)707-710
Number of pages4
JournalArchives of Surgery
Volume114
Issue number6
DOIs
StatePublished - Jun 1979
Externally publishedYes

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