TY - JOUR
T1 - PGT pregnancies have a similar risk for post-partum complications as naturally conceived pregnancies
AU - Srebnik, Naama
AU - Sverdlik Kislasi, Yulia
AU - Amosi-Victor, Danielle
AU - Rotshenker-Olshinka, Keren
AU - Eldar-Geva, Talia
AU - Ben-Ami, Ido
AU - Shonberger, Oshrat
AU - Michaeli, Jennia
AU - Grisaru-Granovsky, Sorina
AU - Rotem, Reut
N1 - Publisher Copyright:
© 2022 Reproductive Healthcare Ltd.
PY - 2023/1
Y1 - 2023/1
N2 - Research question: Do preimplantation genetic testing (PGT) pregnancies have higher post-partum complications compared with naturally conceived pregnancies? Design: Retrospective cohort study conducted in 2008–2020 at the Shaare Zedek Medical Center (SZMC), including all patients aged 18–45 years old who conceived following PGT with a singleton live birth >24 weeks. Data were collected from computerized hospital databases and patient files. There were two control groups: (i) pregnancies following IVF-ICSI (intracytoplasmic sperm injection); (ii) four neighbourhood controls for each case delivery (two women delivered before and two after) of women with naturally conceived pregnancies. Results: Overall, 120 PGT, 779 IVF-ICSI and 3507 naturally conceived deliveries were included. Demographic variables were similar apart from slightly higher age in the PGT (P = 0.003) and ICSI (P = 0.002) groups (31.07 ± 4.38 PGT, 31.66 ± 5.03 ICSI, 28.77 ± 5.72 naturally conceived). Composite post-partum placental-related complications (manual lysis of placenta, revision of uterine cavity, haemoglobin drop ≥3 g/dl, post-partum haemorrhage, need for blood transfusion) were more prevalent in both the PGT and IVF-ICSI groups as opposed to naturally conceived (20.0% versus 18.9% versus 10.3%, respectively, P < 0.001, P = 0.007). In a multivariate regression model PGT was not found to be independently associated with composite post-partum placental-related complications (adjusted odds ratio [aOR] 1.44, 95% confidence interval [CI] 0.83–2.15), while IVF-ICSI pregnancies had increased risk (aOR 1.52, 95% CI 1.20–1.97) compared with natural conception. No difference was found between fresh and frozen cycles or between day 3 and day 5 embryo transfer. Conclusions: PGT pregnancies have a comparable risk of post-partum placental-related complications to naturally conceived pregnancies, unlike IVF-ICSI pregnancies. It is possible that infertility itself is the main mediator for post-partum complications in IVF-ICSI pregnancies.
AB - Research question: Do preimplantation genetic testing (PGT) pregnancies have higher post-partum complications compared with naturally conceived pregnancies? Design: Retrospective cohort study conducted in 2008–2020 at the Shaare Zedek Medical Center (SZMC), including all patients aged 18–45 years old who conceived following PGT with a singleton live birth >24 weeks. Data were collected from computerized hospital databases and patient files. There were two control groups: (i) pregnancies following IVF-ICSI (intracytoplasmic sperm injection); (ii) four neighbourhood controls for each case delivery (two women delivered before and two after) of women with naturally conceived pregnancies. Results: Overall, 120 PGT, 779 IVF-ICSI and 3507 naturally conceived deliveries were included. Demographic variables were similar apart from slightly higher age in the PGT (P = 0.003) and ICSI (P = 0.002) groups (31.07 ± 4.38 PGT, 31.66 ± 5.03 ICSI, 28.77 ± 5.72 naturally conceived). Composite post-partum placental-related complications (manual lysis of placenta, revision of uterine cavity, haemoglobin drop ≥3 g/dl, post-partum haemorrhage, need for blood transfusion) were more prevalent in both the PGT and IVF-ICSI groups as opposed to naturally conceived (20.0% versus 18.9% versus 10.3%, respectively, P < 0.001, P = 0.007). In a multivariate regression model PGT was not found to be independently associated with composite post-partum placental-related complications (adjusted odds ratio [aOR] 1.44, 95% confidence interval [CI] 0.83–2.15), while IVF-ICSI pregnancies had increased risk (aOR 1.52, 95% CI 1.20–1.97) compared with natural conception. No difference was found between fresh and frozen cycles or between day 3 and day 5 embryo transfer. Conclusions: PGT pregnancies have a comparable risk of post-partum placental-related complications to naturally conceived pregnancies, unlike IVF-ICSI pregnancies. It is possible that infertility itself is the main mediator for post-partum complications in IVF-ICSI pregnancies.
KW - IVF
KW - PGT
KW - Post-partum complications
KW - Preimplantation genetic testing
KW - Third stage of labour
UR - http://www.scopus.com/inward/record.url?scp=85143703776&partnerID=8YFLogxK
U2 - 10.1016/j.rbmo.2022.09.009
DO - 10.1016/j.rbmo.2022.09.009
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C2 - 36335017
AN - SCOPUS:85143703776
SN - 1472-6483
VL - 46
SP - 189
EP - 195
JO - Reproductive BioMedicine Online
JF - Reproductive BioMedicine Online
IS - 1
ER -