TY - JOUR
T1 - PGD-derived human embryonic stem cell lines as a powerful tool for the study of human genetic disorders
AU - Ben-Yosef, D.
AU - Malcov, M.
AU - Eiges, R.
PY - 2008/1/30
Y1 - 2008/1/30
N2 - Human embryonic stem (ES) cells are derived from the inner cell mass (ICM) of blastocyst embryos. They are established from spare embryos that have been obtained by in vitro fertilization (IVF) and donated for research purposes. The ICM-derived cell lines have two unique properties, they can be propagated indefinitely in culture and have the potential to develop into practically any cell type in vitro and in vivo. Human embryonic stem (hES) cells carrying specific mutations can be used as a valuable tool for studying genetic disorders in human. One favorable approach to obtain such mutant ES cell lines is their derivation from affected preimplantation genetic diagnosed (PGD) embryos. This review focuses on the importance of deriving human ES cell lines from genetically abnormal embryos, especially in cases where no good cellular and/or animal models exist.
AB - Human embryonic stem (ES) cells are derived from the inner cell mass (ICM) of blastocyst embryos. They are established from spare embryos that have been obtained by in vitro fertilization (IVF) and donated for research purposes. The ICM-derived cell lines have two unique properties, they can be propagated indefinitely in culture and have the potential to develop into practically any cell type in vitro and in vivo. Human embryonic stem (hES) cells carrying specific mutations can be used as a valuable tool for studying genetic disorders in human. One favorable approach to obtain such mutant ES cell lines is their derivation from affected preimplantation genetic diagnosed (PGD) embryos. This review focuses on the importance of deriving human ES cell lines from genetically abnormal embryos, especially in cases where no good cellular and/or animal models exist.
KW - Genetic disorders
KW - Human embryonic stem cells
KW - Preimplantation genetic diagnosis (PGD)
UR - http://www.scopus.com/inward/record.url?scp=39149095271&partnerID=8YFLogxK
U2 - 10.1016/j.mce.2007.11.010
DO - 10.1016/j.mce.2007.11.010
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C2 - 18180094
AN - SCOPUS:39149095271
SN - 0303-7207
VL - 282
SP - 153
EP - 158
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
IS - 1-2
ER -