TY - JOUR
T1 - Petrosynol and petrosolic acid, two novel natural inhibitors of the reverse transcriptase of human immunodeficiency virus from petrosia sp.
AU - Isaacs, Sara
AU - Kashman, Yoel
AU - Loya, Shoshana
AU - Hizi, Amnon
AU - Loya, Yossi
N1 - Funding Information:
Acknowledgements: The research was supportedb y a grant( AI 31790)f rom the National Instituteo f Allergy and InfectionsD iseasesW. e thankM . Litvak for technicala ssistancea nd Dr. M. Ilan for the identificationo f the spongea, nd Prof. A. Mandelbaumt,h eMass SpectroscopCye nter,T echnion,H aifa.
PY - 1993
Y1 - 1993
N2 - Two polyacetylenes from the Red Sea sponge Petrosia sp., Petrosynol (1), and the novel marine natural product petrosolic acid (2) were found effective in inhibitory of the DNA polymerase activities of the reverse transcriptase of human immunodeficiency virus. The structure of compound 2 a novel C44 oxo-octahydroxy-trienetetraynoic carboxylic acid was determined mainly by NMR spectroscopy.
AB - Two polyacetylenes from the Red Sea sponge Petrosia sp., Petrosynol (1), and the novel marine natural product petrosolic acid (2) were found effective in inhibitory of the DNA polymerase activities of the reverse transcriptase of human immunodeficiency virus. The structure of compound 2 a novel C44 oxo-octahydroxy-trienetetraynoic carboxylic acid was determined mainly by NMR spectroscopy.
UR - http://www.scopus.com/inward/record.url?scp=0027437389&partnerID=8YFLogxK
U2 - 10.1016/S0040-4020(01)80571-8
DO - 10.1016/S0040-4020(01)80571-8
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AN - SCOPUS:0027437389
SN - 0040-4020
VL - 49
SP - 10435
EP - 10438
JO - Tetrahedron
JF - Tetrahedron
IS - 45
ER -
