Petrosynol and petrosolic acid, two novel natural inhibitors of the reverse transcriptase of human immunodeficiency virus from petrosia sp.

Sara Isaacs, Yoel Kashman, Shoshana Loya, Amnon Hizi, Yossi Loya

Research output: Contribution to journalArticlepeer-review

Abstract

Two polyacetylenes from the Red Sea sponge Petrosia sp., Petrosynol (1), and the novel marine natural product petrosolic acid (2) were found effective in inhibitory of the DNA polymerase activities of the reverse transcriptase of human immunodeficiency virus. The structure of compound 2 a novel C44 oxo-octahydroxy-trienetetraynoic carboxylic acid was determined mainly by NMR spectroscopy.

Original languageEnglish
Pages (from-to)10435-10438
Number of pages4
JournalTetrahedron
Volume49
Issue number45
DOIs
StatePublished - 1993

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