@article{05f552e9a21641de8e4845a3b78b9643,
title = "Petrosynol and petrosolic acid, two novel natural inhibitors of the reverse transcriptase of human immunodeficiency virus from petrosia sp.",
abstract = "Two polyacetylenes from the Red Sea sponge Petrosia sp., Petrosynol (1), and the novel marine natural product petrosolic acid (2) were found effective in inhibitory of the DNA polymerase activities of the reverse transcriptase of human immunodeficiency virus. The structure of compound 2 a novel C44 oxo-octahydroxy-trienetetraynoic carboxylic acid was determined mainly by NMR spectroscopy.",
author = "Sara Isaacs and Yoel Kashman and Shoshana Loya and Amnon Hizi and Yossi Loya",
note = "Funding Information: Acknowledgements: The research was supportedb y a grant( AI 31790)f rom the National Instituteo f Allergy and InfectionsD iseasesW. e thankM . Litvak for technicala ssistancea nd Dr. M. Ilan for the identificationo f the spongea, nd Prof. A. Mandelbaumt,h eMass SpectroscopCye nter,T echnion,H aifa.",
year = "1993",
doi = "10.1016/S0040-4020(01)80571-8",
language = "אנגלית",
volume = "49",
pages = "10435--10438",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Ltd.",
number = "45",
}
