PET/CT in Disease Detection and Follow-up of Subcutaneous Involvement in Marginal Zone Lymphoma

Tima Davidson, Abraham Avigdor, Yakov Oksman, Ella Nissan, Maya Zlotnick, Bar Chikman, Johnatan Nissan, Elinor Goshen, Simona Ben-Haim, Ohad Benjamini*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: The value of positron emission tomography/computed tomography (PET/CT) in the staging and assessment of treatment response in marginal zone lymphoma (MZL) lymphomas remains controversial. We investigated radiologic characteristics of subcutaneous MZL as imaged on PET/CT scans. Patients and Methods: From the records of a single medical center, for the years 2008 and 2017, we identified subcutaneous lesions in PET/CT scans of patients with histopathologically confirmed MZL in sites other than subcutaneous tissue. Results: Of 571 scans of 178 patients, subcutaneous lesions were found in 20 (11%). Lesions were located in soft tissue structures, mainly along the lateral aspects of the buttocks, thighs and lower and upper back areas, the flank, and the shoulders. Median lengths of the long and short axes of the lesions were 2.0 (range, 1.1-6.0) cm and 0.8 (range, 0.3-2.0) cm, respectively. Median standardized maximum uptake value was 2.3 (range, 0.9-7.6). In 12 patients (60%), MZL was diagnosed at an early stage; 15 (75%) had lymph node involvement and 10 (50%) extranodal involvement. One had spleen and 2 had cutaneous involvement; none had gastric findings. Conclusion: The findings of this study support the usefulness of PET/CT in the detection of subcutaneous MZL as well as in staging and treatment decisions.

Original languageEnglish
Pages (from-to)252-259
Number of pages8
JournalClinical Lymphoma, Myeloma and Leukemia
Issue number4
StatePublished - Apr 2020


  • Extranodal
  • Imaging
  • Low-grade lymphoma
  • Mucosa-associated lymphoid tissue
  • Non-Hodgkin lymphoma


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