Perspective: Chromosomal aneuploidy in leukemia - Lessons from Down Syndrome

Shai Izraeli

Research output: Contribution to journalReview articlepeer-review


Abnormal number of chromosomes, aneuploidy, is the most common abnormality in leukemia and cancer. However, the casual relationship between aneuploidy and cancer is unclear. Additional copies of chromosome 21 are frequently found in leukemic cells. Constitutional trisomy 21 that characterizes Down Syndrome is associated with markedly increased risk for childhood leukemia. In this perspective I review recent studies that suggest that constitutional trisomy 21 promotes leukemic transformation during fetal hematopoiesis. As most of childhood leukemias arise in-utero, these studies are of general relevance to sporadic childhood leukemias.

Original languageEnglish
Pages (from-to)3-6
Number of pages4
JournalHematological Oncology
Issue number1
StatePublished - Mar 2006


  • Aneuploidy
  • Down syndrome
  • Leukemia
  • Trisomy 21


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