Personalized Nutrition by Prediction of Glycemic Responses

David Zeevi, Tal Korem, Niv Zmora, David Israeli, Daphna Rothschild, Adina Weinberger, Orly Ben-Yacov, Dar Lador, Tali Avnit-Sagi, Maya Lotan-Pompan, Jotham Suez, Jemal Ali Mahdi, Elad Matot, Gal Malka, Noa Kosower, Michal Rein, Gili Zilberman-Schapira, Lenka Dohnalová, Meirav Pevsner-Fischer, Rony BikovskyZamir Halpern, Eran Elinav*, Eran Segal

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Summary Elevated postprandial blood glucose levels constitute a global epidemic and a major risk factor for prediabetes and type II diabetes, but existing dietary methods for controlling them have limited efficacy. Here, we continuously monitored week-long glucose levels in an 800-person cohort, measured responses to 46,898 meals, and found high variability in the response to identical meals, suggesting that universal dietary recommendations may have limited utility. We devised a machine-learning algorithm that integrates blood parameters, dietary habits, anthropometrics, physical activity, and gut microbiota measured in this cohort and showed that it accurately predicts personalized postprandial glycemic response to real-life meals. We validated these predictions in an independent 100-person cohort. Finally, a blinded randomized controlled dietary intervention based on this algorithm resulted in significantly lower postprandial responses and consistent alterations to gut microbiota configuration. Together, our results suggest that personalized diets may successfully modify elevated postprandial blood glucose and its metabolic consequences.

Original languageEnglish
Pages (from-to)1079-1094
Number of pages16
JournalCell
Volume163
Issue number5
DOIs
StatePublished - 19 Nov 2015

Funding

FundersFunder number
Benoziyo Endowment Fund for the Advancement of Science
Crown Endowment Fund for Immunological Research
John L. and Vera Schwartz
Lydia Hershkovich
Yael and Rami Ungar, Israel
Leona M. and Harry B. Helmsley Charitable Trust
Foulkes Foundation
European Research Council
Weizmann Institute of Science
Israel Science Foundation
Ministry of Science and Technology, Israel

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