Persistence and complex evolution of fluoroquinolone-resistant Streptococcus pneumoniae Clone

Debby Ben-David*, Mitchell J. Schwaber, Amos Adler, Samira Masarwa, Rotem Edgar, Shiri Navon-Venezia, David Schwartz, Nurith Porat, Tali Kotlovsky, Nikolay Polivkin, Irina Weinberg, Avraham Lazary, Nissim Ohana, Ron Dagan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Prolonged outbreaks of multidrug-resistant Streptococcus pneumoniae in health care facilities are uncommon. We found persistent transmission of a fluroquinolone-resistant S. pneumoniae clone during 2006-2011 in a post-acute care facility in Israel, despite mandatory vaccination and fluoroquinolone restriction. Capsular switch and multiple antimicrobial nonsusceptibility mutations occurred within this single clone. The persistent transmission of fluoroquinolone- resistant S. pneumoniae during a 5-year period underscores the importance of long-term care facilities as potential reservoirs of multidrug-resistant streptococci.

Original languageEnglish
Pages (from-to)799-805
Number of pages7
JournalEmerging Infectious Diseases
Volume20
Issue number5
DOIs
StatePublished - May 2014
Externally publishedYes

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