Permissive hypercapnia ventilation in patients with severe pulmonary blast injury

Patrick Sorkine, Oded Szold*, Yoram Kluger, Pinchas Halpern, Avi A. Weinbroum, Ron Fleishon, Aviel Silbiger, Valery Rudick

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objectives: To describe our experience with the use of limited peak inspiratory pressure (PIP), volume-controlled ventilation, and permissive hypercapnia in patients with severe pulmonary blast injury. Methods: Patients with pulmonary blast injury were ventilated using volume-controlled, synchronized intermittent mandatory ventilation. Whenever PIP exceeded 40 cm H2O, the tidal volume was decreased to maintain PIP at less than 40 cm H2O. Whenever the arterial pH fell below 7.2, the ventilator rate was increased in increments of 2 breaths per minute until the arterial pH rose to 7.25. Results: Between 1994 and 1996, 17 patients with severe pulmonary blast injury (10 from enclosed space explosions and seven from open space ones), requiring mechanical ventilatory support were admitted to our intensive care unit. Four patients developed increasing Paco2 levels (to 93 ± 12 mm Hg) associated with the reduction in arterial pH that was corrected by increasing the ventilator rate. There was evidence of ventilator-induced pulmonary barotrauma. Of the 17 patients, 15 patients (88%) survived. Conclusions: Limited PIP in a volume-controlled ventilation is a useful and safe mode of mechanical ventilation in patients with pulmonary blast injury.

Original languageEnglish
Pages (from-to)35-38
Number of pages4
JournalJournal of Trauma
Issue number1
StatePublished - Jul 1998


  • Permissive hypercapnia
  • Pulmonary blast injury
  • Small tidal volume


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