Permeation through a lamellar stack of lipid mixtures

Takuma Hoshino, Shigeyuki Komura, David Andelman

Research output: Contribution to journalArticlepeer-review

Abstract

We study material transport and permeation through a lamellar stack of multi-component lipid membranes by performing Monte Carlo simulations of a stacked two-dimensional Ising model in the presence of permeants. In the model, permeants are transported through the stack via in-plane lipid clusters, which are inter-connected in the vertical direction. These clusters are formed transiently by concentration fluctuations of the lipid mixture, and the permeation process is affected especially close to the critical temperature of the binary mixture. We show that the permeation rate decays exponentially as a function of temperature and permeant lateral size, whereas the dependency on the characteristic waiting time obeys a stretched exponential function. The material transport through such lipid clusters can be significantly affected around physiological temperatures.

Original languageEnglish
Article number18004
JournalJournal de Physique (Paris), Lettres
Volume120
Issue number1
DOIs
StatePublished - Oct 2017

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