TY - GEN
T1 - Peripheral vascular occlusions leading to gangrene and amputations in antiphospholipid antibody positive patients
AU - Asherson, Ronald A.
AU - Cervera, Ricard
AU - Shoenfeld, Yehuda
PY - 2007/6
Y1 - 2007/6
N2 - Twenty-one cases from several medical centers (Brazil, Italy, Serbia, South Africa, Israel, and the United Kingdom) with severe peripheral vascular disease progressing to amputations of limbs/digits, all of whom tested positive for antiphospholipid antibodies, are documented. The patients were suffering from either systemic lupus erythematosus, discoid LE, "primary" antiphospholipid syndrome (PAPS), "lupus-like" disease, undifferentiated connective tissue disease. A high frequency of livedo reticularis preceding the arterial occlusions in our series of patients who subsequently progressed to ischemic necrosis and amputation of limbs/digits was noted. Five of the 10 patients, in whom histopathological studies had been performed, demonstrated the typical vasculopathy seen with the antiphospholipid syndrome ("APS vasculopathy"). Complicating vasculitis was present in seven of the patients. Five of the patients developed severe peripheral vascular disease during the course of the catastrophic antiphospholipid (Asherson's) syndrome.
AB - Twenty-one cases from several medical centers (Brazil, Italy, Serbia, South Africa, Israel, and the United Kingdom) with severe peripheral vascular disease progressing to amputations of limbs/digits, all of whom tested positive for antiphospholipid antibodies, are documented. The patients were suffering from either systemic lupus erythematosus, discoid LE, "primary" antiphospholipid syndrome (PAPS), "lupus-like" disease, undifferentiated connective tissue disease. A high frequency of livedo reticularis preceding the arterial occlusions in our series of patients who subsequently progressed to ischemic necrosis and amputation of limbs/digits was noted. Five of the 10 patients, in whom histopathological studies had been performed, demonstrated the typical vasculopathy seen with the antiphospholipid syndrome ("APS vasculopathy"). Complicating vasculitis was present in seven of the patients. Five of the patients developed severe peripheral vascular disease during the course of the catastrophic antiphospholipid (Asherson's) syndrome.
KW - Amputations
KW - Antiphospholipid antibodies
KW - Catastrophic antiphospholipid (Asherson's) syndrome
KW - Livedo reticularis
KW - Peripheral vascular diseases
KW - Primary antiphosholipid syndrome
KW - Systemic lupus erythematosus
KW - Vasculitis
UR - http://www.scopus.com/inward/record.url?scp=34948874137&partnerID=8YFLogxK
U2 - 10.1196/annals.1422.055
DO - 10.1196/annals.1422.055
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C2 - 17894017
AN - SCOPUS:34948874137
SN - 157331708X
SN - 9781573317085
T3 - Annals of the New York Academy of Sciences
SP - 515
EP - 529
BT - Autoimmunity, Part D
PB - Blackwell Publishing Inc.
ER -