@article{b6cb3babe02b419996960bf5ac0e2c9a,
title = "Peripheral-type benzodiazepine-binding sites in platelets of schizophrenics with and without tardive dyskinesia",
abstract = "The density of peripheral-type benzodiazepine (BZ)-binding sites was studied in platelets of 10 medicated chronic schizophrenics with tardive dyskinesia (TD), 10 medicated chronic schizophrenics without TD, 7 drug-free schizophrenics, and 10 normal controls. The age range of the study population was 36-60 years. Age and sex distribution were similar in all 4 groups. The unmedicated schizophrenics did not differ in their maximal binding capacity from the healthy controls. A significant decrease in the density of peripheral-type BZ-binding sites in platelets was observed in treated schizophrenics both with and without TD in comparison to controls and untreated schizophrenics. The reduction in [3H]PK 11195 binding was more pronounced in TD patients (31.3\% of controls) than in patients without TD (21.1\% of controls). However, this parameter failed to discriminate statistically between TD and non-TD medicated schizophrenics.",
author = "Ronit Weizman and Zehava Tanne and Leon Karp and Sam Tyano and Moshe Gavish",
note = "Funding Information: This study was supported in part by grants from the Israel Institute for Psychobiology (the Charles E. Smith Family Foundation) (to M.G.), the Fund for Basic Research administered by the Israel Academy of Sciences and Humanities (to M.G.), and the Israel Ministry of Health (to M.G. and R.W.). We thank Miss Ruth Singer for typing the manuscript.",
year = "1986",
month = aug,
day = "11",
doi = "10.1016/0024-3205(86)90512-6",
language = "אנגלית",
volume = "39",
pages = "549--555",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "6",
}