Abstract
Isolated limb perfusion (ILP) is a well documented treatment modality for locally advanced limb melanoma. Recently, cisplatinum has been added to the chemotherapeutic arsenal used in this procedure. The long term effects of the procedure and the chemotherapy upon the perfused limb were studied using non-invasive blood flow measurements. Fourteen patients were treated by ILP for locally advanced melanoma of the lower limbs using cisplatinum. The following non-invasive vascular parameters were studied in perfused and non-perfused limb: Pulse, BP index and PVR as well as laser-doppler perfusion monitoring of the limb microvasculature. There were no changes observed in all macro-vascular parameters studied of perfused in comparison to non-perfused limb. Neither were there any microvascular changes monitored by the laser dopler in perfused versus non-perfused limbs. These observations suggest that ILP with cisplatinum has no long term adverse effects upon the macro- and micro-vasculature of perfused limbs as monitored by the non-invasive blood flow studies.
| Original language | English |
|---|---|
| Pages (from-to) | 137-139 |
| Number of pages | 3 |
| Journal | Regional Cancer Treatment |
| Volume | 6 |
| Issue number | 3 |
| State | Published - 1993 |
| Externally published | Yes |
Keywords
- cisplatinum
- limb perfusion
- vascular changes
