Peripheral benzodiazepine binding sites on platelet membranes are increased during diazepam treatment of anxious patients

Ronit Weizman, Zehava Tanne, Michel Granek, Leon Karp, Mira Golomb, Sam Tyano, Moshe Gavish*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Reduced (24%) [3H]PK 11195 binding capacity to platelet membranes was observed in anxious patients in comparison to age- and sex-matched normal controls. Four weeks of diazepam treatment induced elevation (69%) in the maximal number of binding sites, and 1 week of drug withdrawal resulted in a slight decrease (16%) in 'peripheral' benzodiazepine binding sites as compared to their level during treatment.

Original languageEnglish
Pages (from-to)289-292
Number of pages4
JournalEuropean Journal of Pharmacology
Volume138
Issue number2
DOIs
StatePublished - 19 Jun 1987

Funding

FundersFunder number
Israel Mimstry of Health Tins

    Keywords

    • Diazepam
    • Generalized anxiety disorder
    • Peripheral benzodiazepine binding sites
    • [H]PK 11195

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