Peripartum changes in free and protein-bound digoxinlike immunoreactive factor

P. Jakobi*, S. Kol, A. Weissman, N. Krivoy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The appearance of free digoxinlike immunoreactive factor in pregnancy and its rapid disappearance after delivery is well documented. The protein-bound fraction, a common component of plasma, does not change during pregnancy. We investigated the peripartum changes in both free and protein-bound fractions of digoxinlike immunoreactive factor and observed different peripartum patterns of those fractions. While the disappearance of the free fraction after delivery was reconfirmed, the protein-bound fraction exhibited a biphasic pattern: a rapid decrease after delivery with a slow increase to predelivery levels seven weeks later. The disappearance of free digoxinlike immunoreactive factor after delivery may reflect the elimination of the fetal source. The changes in the protein-bound fraction imply that the fraction may also vary in certain clinical situations and may be produced in response to certain homeostatic changes and suggest a possible interaction between fetal and maternal systems that produce digoxinlike immunoreactive factor during pregnancy.

Original languageEnglish
Pages (from-to)127-130
Number of pages4
JournalThe Journal of reproductive medicine
Issue number2
StatePublished - 1992
Externally publishedYes


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