Perioperative blood transfusion in cancer patients undergoing laparoscopic colorectal resection: Risk factors and impact on survival

R. Ghinea, R. Greenberg, I. White, E. Sacham-Shmueli, H. Mahagna, S. Avital

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Perioperative blood transfusion has been associated with a poor prognosis in patients undergoing surgery for colorectal cancer. The aim of this study was to evaluate risk factors for blood transfusion and its impact on long-term outcome exclusively in patients undergoing laparoscopic surgery for curable colorectal cancer. Methods: Data were retrieved from a prospectively collected database of patients who underwent laparoscopic surgery for curable colorectal cancer over a 6-year period. Long-term data were collected from our outpatient clinic and personal contact when necessary. Results: Two hundred and one patients underwent laparoscopic surgery for curable colorectal cancer (stage I-III). Sixty-eight (33.8 %) received blood transfusions during or after surgery. These patients were typically older, had lower preoperative hemoglobin levels, had a more advanced cancer, had a higher Charlson score, had a higher rate of complications and had a higher conversion rate. Kaplan-Meier overall survival analysis was significantly worse in patients who received blood transfusions (P = 0.004). Decreased disease-free survival was also observed in transfused patients; however, this did not reach statistical significance (P = 0.21). A multivariate analysis revealed that transfusion was not an independent risk factor for decreased overall and disease-free survival. The Charlson score was the only independent risk factor for overall survival (OR = 2.1, P = 0.002). Independent factors affecting disease-free survival were stage of disease, Charlson score and, to a lesser degree, age and body mass index. Conclusions: Perioperative blood transfusion is associated with decreased long-term survival in patients undergoing laparoscopic resection for colorectal cancer. However, this association apparently reflects the poorer medical condition of patients requiring surgery and not a causative relationship.

Original languageEnglish
Pages (from-to)549-554
Number of pages6
JournalTechniques in Coloproctology
Volume17
Issue number5
DOIs
StatePublished - Oct 2013

Keywords

  • Blood transfusion
  • Colorectal neoplasms
  • Laparoscopic resection
  • Long-term survival
  • Prognosis

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