Periodontitis and cardiovascular diseases: Consensus report

Mariano Sanz*, Alvaro Marco del Castillo, Søren Jepsen, Jose R. Gonzalez-Juanatey, Francesco D’Aiuto, Philippe Bouchard, Iain Chapple, Thomas Dietrich, Israel Gotsman, Filippo Graziani, David Herrera, Bruno Loos, Phoebus Madianos, Jean Baptiste Michel, Pablo Perel, Burkert Pieske, Lior Shapira, Michael Shechter, Maurizio Tonetti, Charalambos VlachopoulosGernot Wimmer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: In Europe cardiovascular disease (CVD) is responsible for 3.9 million deaths (45% of deaths), being ischaemic heart disease, stroke, hypertension (leading to heart failure) the major cause of these CVD related deaths. Periodontitis is also a chronic non-communicable disease (NCD) with a high prevalence, being severe periodontitis, affecting 11.2% of the world's population, the sixth most common human disease. Material and Methods: There is now a significant body of evidence to support independent associations between severe periodontitis and several NCDs, in particular CVD. In 2012 a joint workshop was held between the European Federation of Periodontology (EFP) and the American Academy of Periodontology to review the literature relating periodontitis and systemic diseases, including CVD. In the last five years important new scientific information has emerged providing important emerging evidence to support these associations. Results and Conclusions: The present review reports the proceedings of the workshop jointly organised by the EFP and the World Heart Federation (WHF), which has updated the existing epidemiological evidence for significant associations between periodontitis and CVD, the mechanistic links and the impact of periodontal therapy on cardiovascular and surrogate outcomes. This review has also focused on the potential risk and complications of periodontal therapy in patients on anti thrombotic therapy and has made recommendations for dentists, physicians and for patients visiting both the dental and medical practices.

Original languageEnglish
Pages (from-to)268-288
Number of pages21
JournalJournal of Clinical Periodontology
Issue number3
StatePublished - 1 Mar 2020


  • anti thrombotic therapy
  • atherosclerosis
  • bateremia
  • cardiovascular disease
  • chronic inflammation
  • periodontal therapy
  • periodontitis


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