@article{e9d5e5848a3a4cb99ac699ca07729188,
title = "Periodontal Stem Cells: a Historical Background and Current Perspectives",
abstract = "In this review we discuss the historical perspective of stem cell populations from oral tissues in light of our current understanding of stem cell biology. Stem cells and their niches have been identified in the periodontium starting from the late 1970s. Applying new criteria for the identification and characterization reveals that oral tissues comprise a multipotent primitive neural crest-like stem cell population capable of differentiating into neural crest derived cell lineages of the cranial-facial zone. This population supplies cells to a more restricted stem cell type with tissue specific epigenetic memory that differentiates into cell lineages characteristic of their tissue origin. We believe that the microenvironment plays an essential role in maintaining stem cell populations and directing their migration and differentiation, and that this factor needs to be considered for utilization of stem cell-based therapy for periodontal regeneration and regenerative dental medicine.",
keywords = "Alveolar bone, Cementum, Endosteal space, Extracellular matrix, Gingiva, Microenvironment, Neural crest, Oral mucosa, Paravascular zone, Periodontal ligament, Periodontal regeneration, Progenitors, Stem cell differentiation, Stem cell niche, Stem cells",
author = "Sandu Pitaru and Narayanan, {A. Sampath} and Anusha Etikala and Sandra Treves-Manusevitz",
note = "Publisher Copyright: {\textcopyright} 2013, Springer International Publishing AG.",
year = "2014",
month = mar,
doi = "10.1007/s40496-013-0003-6",
language = "אנגלית",
volume = "1",
pages = "26--33",
journal = "Current Oral Health Reports",
issn = "2196-3002",
publisher = "Springer Science and Business Media Deutschland GmbH",
number = "1",
}