Periodic syndromes of childhood.

R. Arav-Boger, Z. Spirer

Research output: Contribution to journalReview articlepeer-review


Periodic syndromes of childhood comprise a large group of disorders that require long-term follow-up to be diagnosed. Several disorders have fixed rhythmicity and are therefore identified more easily. Other disorders are usually diagnosed after a prolonged follow-up and exclusion of other more common childhood diseases. In general, most of the periodic fever syndromes have a benign prognosis, and their symptomatology tends to improve in the long term. Periodic syndromes without fever or chronic pain syndromes constitute not only a diagnostic dilemma but also a therapeutic challenge. A general diagnostic approach to the periodic syndromes is outlined in Figure 1.

Original languageEnglish
Pages (from-to)389-428
Number of pages40
JournalAdvances in Pediatrics
StatePublished - 1997


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