TY - JOUR
T1 - Periodic structurally similar oligomers are found on one side of the axes of symmetry in the lac, trp, and gal operators
AU - Nussinov, Ruth
AU - Lennon, Gregory G.
N1 - Funding Information:
We would like to thank Drs. W. Goad and T. F. Smith for discussions. This work was performed under the auspices of the United States Department of Energy.
PY - 1984/10
Y1 - 1984/10
N2 - Three well-defined E. coli operator regions were examined for recurring conformational deviation from a regular B-DNA helix. All three, the lac, trp, and gal. show repeats of the same set of neighboring helical twist angles. These angles recur with a periodicity equal to the helix periodicity on one side of the operator’s axes of symmetry. The probability that their occurrence is random was found to be extremely small. Therefore, we propose that in addition to specific bases, repeating twist angle patterns are likely to be among the local parameters involved in repressor-operator recognition.
AB - Three well-defined E. coli operator regions were examined for recurring conformational deviation from a regular B-DNA helix. All three, the lac, trp, and gal. show repeats of the same set of neighboring helical twist angles. These angles recur with a periodicity equal to the helix periodicity on one side of the operator’s axes of symmetry. The probability that their occurrence is random was found to be extremely small. Therefore, we propose that in addition to specific bases, repeating twist angle patterns are likely to be among the local parameters involved in repressor-operator recognition.
UR - http://www.scopus.com/inward/record.url?scp=0021638424&partnerID=8YFLogxK
U2 - 10.1080/07391102.1984.10507574
DO - 10.1080/07391102.1984.10507574
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AN - SCOPUS:0021638424
SN - 0739-1102
VL - 2
SP - 387
EP - 395
JO - Journal of Biomolecular Structure and Dynamics
JF - Journal of Biomolecular Structure and Dynamics
IS - 2
ER -