Perinatal Vasoconstrictive Renal Insufficiency Associated with Maternal Nimesulide Use

Daniel Landau, Ilan Shelef, Hanna Polacheck, M. J. Pharm, Kyla Marks, Gershon Holcberg

Research output: Contribution to journalArticlepeer-review


A full-term newborn developed oliguric renal failure at 24 hr of life, which persisted for several days. Her mother ingested therapeutic doses of nimesulide, a nonsteroidal anti-inflammatory (cyclo-oxygenase-2 inhibitor) drug, during the last 2 weeks of pregnancy. She was found at delivery to have developed oligohydramnion, esophagitis, and a bleeding peptic ulcer. The infant's fractional excretion of sodium was very low (0.5%) pointing for a severe vasoconstrictive mechanism involved. Renal sonogram showed hyperechogenic medullary papillae, which resolved during convalescence. This case emphasizes the importance of renal prostagandins in the control of vascular tone and sodium homeostasis. This is the first report of an adverse effect of fetal renal circulation by maternal ingestion of nimesulide.

Original languageEnglish
Pages (from-to)441-444
Number of pages4
JournalAmerican Journal of Perinatology
StatePublished - Sep 1999
Externally publishedYes


  • Renal failure, acute
  • nimesulide
  • nonsteroidal anti-inflammatory drugs


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