Perinatal hematological profile of newborn infants with Candida antenatal infections

Baruch Wolach, Sara Bogger-Goren, Robin Whyte

Research output: Contribution to journalArticlepeer-review


We serially studied hematological profiles of 8 newborns with proven antenatal Candida chorioamnionitis and funisitis. Candida albicans was cultured from various sources in the infants; blood and CSF cultures were all negative. Seven of the 8 were premature; 5 were sick. We statistically compared hematological data of the ‘well’ and ‘sick’ babies. The latter showed neutrophilia (mean 52,381 vs. 11, 326/µl, p < 0.01) accompanied by significant elevation of nonsegmented granulocytes (NSG) and a NSG/neutrophil ratio greater than 0.3. Significant monocytosis (mean 7,836 vs. 2,869/µl, p < 0.01) and eosinophilia (mean 4,723 vs. 782/µl, p < 0.05) were also noted. Remarkable toxic granulations, vacuolization, and Döhle bodies were found in the neutrophils of the ‘sick’ newborns. Hematological profiles correlated with the infants’ clinical condition.

Original languageEnglish
Pages (from-to)5-12
Number of pages8
Issue number1
StatePublished - 1991


  • Absolute monocyte count
  • Absolute neutrophil count
  • Neutrophil morphology
  • Nonsegmented granulocyte/neutrophil ratio


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