Perinatal hematological profile of newborn infants with Candida antenatal infections

Baruch Wolach, Sara Bogger-Goren, Robin Whyte

Research output: Contribution to journalArticlepeer-review

Abstract

We serially studied hematological profiles of 8 newborns with proven antenatal Candida chorioamnionitis and funisitis. Candida albicans was cultured from various sources in the infants; blood and CSF cultures were all negative. Seven of the 8 were premature; 5 were sick. We statistically compared hematological data of the ‘well’ and ‘sick’ babies. The latter showed neutrophilia (mean 52,381 vs. 11, 326/µl, p < 0.01) accompanied by significant elevation of nonsegmented granulocytes (NSG) and a NSG/neutrophil ratio greater than 0.3. Significant monocytosis (mean 7,836 vs. 2,869/µl, p < 0.01) and eosinophilia (mean 4,723 vs. 782/µl, p < 0.05) were also noted. Remarkable toxic granulations, vacuolization, and Döhle bodies were found in the neutrophils of the ‘sick’ newborns. Hematological profiles correlated with the infants’ clinical condition.

Original languageEnglish
Pages (from-to)5-12
Number of pages8
JournalNeonatology
Volume59
Issue number1
DOIs
StatePublished - 1991

Keywords

  • Absolute monocyte count
  • Absolute neutrophil count
  • Neutrophil morphology
  • Nonsegmented granulocyte/neutrophil ratio

Fingerprint

Dive into the research topics of 'Perinatal hematological profile of newborn infants with Candida antenatal infections'. Together they form a unique fingerprint.

Cite this