Perinatal hematological profile of newborn infants with Candida antenatal infections

Baruch Wolach; Sara Bogger-Goren; Robin Whyte

doi:10.1159/000243316

Perinatal hematological profile of newborn infants with Candida antenatal infections

Baruch Wolach, Sara Bogger-Goren, Robin Whyte

Clinical Departments

Research output: Contribution to journal › Article › peer-review

Abstract

We serially studied hematological profiles of 8 newborns with proven antenatal Candida chorioamnionitis and funisitis. Candida albicans was cultured from various sources in the infants; blood and CSF cultures were all negative. Seven of the 8 were premature; 5 were sick. We statistically compared hematological data of the ‘well’ and ‘sick’ babies. The latter showed neutrophilia (mean 52,381 vs. 11, 326/µl, p < 0.01) accompanied by significant elevation of nonsegmented granulocytes (NSG) and a NSG/neutrophil ratio greater than 0.3. Significant monocytosis (mean 7,836 vs. 2,869/µl, p < 0.01) and eosinophilia (mean 4,723 vs. 782/µl, p < 0.05) were also noted. Remarkable toxic granulations, vacuolization, and Döhle bodies were found in the neutrophils of the ‘sick’ newborns. Hematological profiles correlated with the infants’ clinical condition.

Original language	English
Pages (from-to)	5-12
Number of pages	8
Journal	Neonatology
Volume	59
Issue number	1
DOIs	https://doi.org/10.1159/000243316
State	Published - 1991

Keywords

Absolute monocyte count
Absolute neutrophil count
Neutrophil morphology
Nonsegmented granulocyte/neutrophil ratio

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title = "Perinatal hematological profile of newborn infants with Candida antenatal infections",

abstract = "We serially studied hematological profiles of 8 newborns with proven antenatal Candida chorioamnionitis and funisitis. Candida albicans was cultured from various sources in the infants; blood and CSF cultures were all negative. Seven of the 8 were premature; 5 were sick. We statistically compared hematological data of the {\textquoteleft}well{\textquoteright} and {\textquoteleft}sick{\textquoteright} babies. The latter showed neutrophilia (mean 52,381 vs. 11, 326/µl, p < 0.01) accompanied by significant elevation of nonsegmented granulocytes (NSG) and a NSG/neutrophil ratio greater than 0.3. Significant monocytosis (mean 7,836 vs. 2,869/µl, p < 0.01) and eosinophilia (mean 4,723 vs. 782/µl, p < 0.05) were also noted. Remarkable toxic granulations, vacuolization, and D{\"o}hle bodies were found in the neutrophils of the {\textquoteleft}sick{\textquoteright} newborns. Hematological profiles correlated with the infants{\textquoteright} clinical condition.",

keywords = "Absolute monocyte count, Absolute neutrophil count, Neutrophil morphology, Nonsegmented granulocyte/neutrophil ratio",

author = "Baruch Wolach and Sara Bogger-Goren and Robin Whyte",

year = "1991",

doi = "10.1159/000243316",

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AU - Bogger-Goren, Sara

AU - Whyte, Robin

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N2 - We serially studied hematological profiles of 8 newborns with proven antenatal Candida chorioamnionitis and funisitis. Candida albicans was cultured from various sources in the infants; blood and CSF cultures were all negative. Seven of the 8 were premature; 5 were sick. We statistically compared hematological data of the ‘well’ and ‘sick’ babies. The latter showed neutrophilia (mean 52,381 vs. 11, 326/µl, p < 0.01) accompanied by significant elevation of nonsegmented granulocytes (NSG) and a NSG/neutrophil ratio greater than 0.3. Significant monocytosis (mean 7,836 vs. 2,869/µl, p < 0.01) and eosinophilia (mean 4,723 vs. 782/µl, p < 0.05) were also noted. Remarkable toxic granulations, vacuolization, and Döhle bodies were found in the neutrophils of the ‘sick’ newborns. Hematological profiles correlated with the infants’ clinical condition.

AB - We serially studied hematological profiles of 8 newborns with proven antenatal Candida chorioamnionitis and funisitis. Candida albicans was cultured from various sources in the infants; blood and CSF cultures were all negative. Seven of the 8 were premature; 5 were sick. We statistically compared hematological data of the ‘well’ and ‘sick’ babies. The latter showed neutrophilia (mean 52,381 vs. 11, 326/µl, p < 0.01) accompanied by significant elevation of nonsegmented granulocytes (NSG) and a NSG/neutrophil ratio greater than 0.3. Significant monocytosis (mean 7,836 vs. 2,869/µl, p < 0.01) and eosinophilia (mean 4,723 vs. 782/µl, p < 0.05) were also noted. Remarkable toxic granulations, vacuolization, and Döhle bodies were found in the neutrophils of the ‘sick’ newborns. Hematological profiles correlated with the infants’ clinical condition.

KW - Absolute monocyte count

KW - Absolute neutrophil count

KW - Neutrophil morphology

KW - Nonsegmented granulocyte/neutrophil ratio

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Perinatal hematological profile of newborn infants with Candida antenatal infections

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Keywords

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