Peri-implant disease affects systemic complete blood count values—an experimental in vivo study

Liat Chaushu, Haim Tal, Anton Sculean, Blanca Fernández-Tomé, Gavriel Chaushu

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To assess complete blood count (CBC) dynamics following ligature removal and open flap debridement in experimental peri-implantitis in dogs. Materials and methods: Seven male beagle dogs were included in the study. Four rough-surface implants were placed pair-wise in both sides of the mandible 14 weeks after tooth extraction. Second stage surgery was performed after 14 weeks. Experimental peri-implantitis was initiated 3 weeks later by ligature placement around the healing caps thus facilitating plaque accumulation and inducing inflammation and destruction of peri-implant tissues. Ligature removal and open flap debridement were performed 11 weeks later. The CBC values were compared with baseline after each procedure. Wilcoxon paired tests were conducted in order to identify statistically significant differences between baseline data and values obtained after each procedure. Results: Following experimental peri-implantitis, statistically significant (p < 0.05) increases were noted for white blood cells—WBC (9.62 ± 4.34 vs. 6.48 ± 1.34 cells per microliter of blood × 1000), hemoglobin—Hb (15.25 ± 0.94 vs. 13.52 ± 1.46, grams per deciliter), red blood cells—RBC (7.26 ± 0.79 vs. 5.9 ± 0.61 cells per microliter of blood × 1000), mean corpuscular hemoglobin—MCH (23.64 ± 0.96 vs. 23.16 ± 0.83 picograms/cell), platelets—PLT (349.86 ± 51.05 vs. 277.57 ± 66 cells per microliter of blood × 1000), and mean corpuscular hemoglobin concentration—MCHC (35.83 ± 0.27 vs. 31.04 ± 0.48 grams per deciliter). A statistically significant (p < 0.05) decrease in values was noted only for after ligature removal and open flap debridement. Mean corpuscular volume—MCV values were significantly lower (65.99 ± 2.31 vs. 74.65 ± 2.85 femtoliter) following 1st ligature. Values returned to baseline after open flap debridement. Conclusions: Within its limits, the present data suggest that experimentally induced peri-implantitis affects CBC values. Following surgical treatment, CBC values returned to normal. Clinical relevance This is the first study suggesting possible relationships between peri-implantitis and CBC values. Future studies, confirming such correlation, may provide an insight into the importance of peri-implant maintenance and treatment to minimize supporting tissues disease and reduce systemic effects.

Original languageEnglish
Pages (from-to)4531-4539
Number of pages9
JournalClinical Oral Investigations
Volume24
Issue number12
DOIs
StatePublished - Dec 2020

Keywords

  • Biomarkers
  • Bone loss
  • Dental implants
  • Infection control
  • Oral-systemic diseases

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