TY - JOUR
T1 - Peri-implant disease affects systemic complete blood count values—an experimental in vivo study
AU - Chaushu, Liat
AU - Tal, Haim
AU - Sculean, Anton
AU - Fernández-Tomé, Blanca
AU - Chaushu, Gavriel
N1 - Publisher Copyright:
© 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2020/12
Y1 - 2020/12
N2 - Objectives: To assess complete blood count (CBC) dynamics following ligature removal and open flap debridement in experimental peri-implantitis in dogs. Materials and methods: Seven male beagle dogs were included in the study. Four rough-surface implants were placed pair-wise in both sides of the mandible 14 weeks after tooth extraction. Second stage surgery was performed after 14 weeks. Experimental peri-implantitis was initiated 3 weeks later by ligature placement around the healing caps thus facilitating plaque accumulation and inducing inflammation and destruction of peri-implant tissues. Ligature removal and open flap debridement were performed 11 weeks later. The CBC values were compared with baseline after each procedure. Wilcoxon paired tests were conducted in order to identify statistically significant differences between baseline data and values obtained after each procedure. Results: Following experimental peri-implantitis, statistically significant (p < 0.05) increases were noted for white blood cells—WBC (9.62 ± 4.34 vs. 6.48 ± 1.34 cells per microliter of blood × 1000), hemoglobin—Hb (15.25 ± 0.94 vs. 13.52 ± 1.46, grams per deciliter), red blood cells—RBC (7.26 ± 0.79 vs. 5.9 ± 0.61 cells per microliter of blood × 1000), mean corpuscular hemoglobin—MCH (23.64 ± 0.96 vs. 23.16 ± 0.83 picograms/cell), platelets—PLT (349.86 ± 51.05 vs. 277.57 ± 66 cells per microliter of blood × 1000), and mean corpuscular hemoglobin concentration—MCHC (35.83 ± 0.27 vs. 31.04 ± 0.48 grams per deciliter). A statistically significant (p < 0.05) decrease in values was noted only for after ligature removal and open flap debridement. Mean corpuscular volume—MCV values were significantly lower (65.99 ± 2.31 vs. 74.65 ± 2.85 femtoliter) following 1st ligature. Values returned to baseline after open flap debridement. Conclusions: Within its limits, the present data suggest that experimentally induced peri-implantitis affects CBC values. Following surgical treatment, CBC values returned to normal. Clinical relevance This is the first study suggesting possible relationships between peri-implantitis and CBC values. Future studies, confirming such correlation, may provide an insight into the importance of peri-implant maintenance and treatment to minimize supporting tissues disease and reduce systemic effects.
AB - Objectives: To assess complete blood count (CBC) dynamics following ligature removal and open flap debridement in experimental peri-implantitis in dogs. Materials and methods: Seven male beagle dogs were included in the study. Four rough-surface implants were placed pair-wise in both sides of the mandible 14 weeks after tooth extraction. Second stage surgery was performed after 14 weeks. Experimental peri-implantitis was initiated 3 weeks later by ligature placement around the healing caps thus facilitating plaque accumulation and inducing inflammation and destruction of peri-implant tissues. Ligature removal and open flap debridement were performed 11 weeks later. The CBC values were compared with baseline after each procedure. Wilcoxon paired tests were conducted in order to identify statistically significant differences between baseline data and values obtained after each procedure. Results: Following experimental peri-implantitis, statistically significant (p < 0.05) increases were noted for white blood cells—WBC (9.62 ± 4.34 vs. 6.48 ± 1.34 cells per microliter of blood × 1000), hemoglobin—Hb (15.25 ± 0.94 vs. 13.52 ± 1.46, grams per deciliter), red blood cells—RBC (7.26 ± 0.79 vs. 5.9 ± 0.61 cells per microliter of blood × 1000), mean corpuscular hemoglobin—MCH (23.64 ± 0.96 vs. 23.16 ± 0.83 picograms/cell), platelets—PLT (349.86 ± 51.05 vs. 277.57 ± 66 cells per microliter of blood × 1000), and mean corpuscular hemoglobin concentration—MCHC (35.83 ± 0.27 vs. 31.04 ± 0.48 grams per deciliter). A statistically significant (p < 0.05) decrease in values was noted only for after ligature removal and open flap debridement. Mean corpuscular volume—MCV values were significantly lower (65.99 ± 2.31 vs. 74.65 ± 2.85 femtoliter) following 1st ligature. Values returned to baseline after open flap debridement. Conclusions: Within its limits, the present data suggest that experimentally induced peri-implantitis affects CBC values. Following surgical treatment, CBC values returned to normal. Clinical relevance This is the first study suggesting possible relationships between peri-implantitis and CBC values. Future studies, confirming such correlation, may provide an insight into the importance of peri-implant maintenance and treatment to minimize supporting tissues disease and reduce systemic effects.
KW - Biomarkers
KW - Bone loss
KW - Dental implants
KW - Infection control
KW - Oral-systemic diseases
UR - http://www.scopus.com/inward/record.url?scp=85084838908&partnerID=8YFLogxK
U2 - 10.1007/s00784-020-03318-0
DO - 10.1007/s00784-020-03318-0
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C2 - 32415398
AN - SCOPUS:85084838908
SN - 1432-6981
VL - 24
SP - 4531
EP - 4539
JO - Clinical Oral Investigations
JF - Clinical Oral Investigations
IS - 12
ER -