TY - JOUR
T1 - Performance of the marmoset monkey on computerized tasks of attention and working memory
AU - Spinelli, Simona
AU - Pennanen, Luis
AU - Dettling, Andrea C.
AU - Feldon, Joram
AU - Higgins, Guy A.
AU - Pryce, Christopher R.
N1 - Funding Information:
We are extremely grateful to Jeanne Michel for marmoset husbandry and care, Barbara König for collaboration, and to Giancarlo Tomio for writing the PERL computer programs for analysis of the results output generated by the CANTAB software. Research funding was provided by the Swiss National Science Foundation (grants 31.055618.98 and 31.67791.02) and the Swiss Federal Institute of Technology Zurich. Simona Spinelli was in receipt of a Studentship funded by Hoffmann La Roche, Basel, Switzerland.
PY - 2004/4
Y1 - 2004/4
N2 - The CAmbridge Neuropsychological Test Automated Battery (CANTAB) is a computerised battery of neuropsychological tests presented as stimuli on a touch-sensitive computer screen that has been used to assess a wide range of cognitive functions in neuropsychiatric patients, healthy volunteers, and species of non-human primate, primarily the rhesus macaque. The common marmoset is a small-bodied, tractable simian primate that breeds well under laboratory conditions. This primate has been quite extensively studied in terms of its abilities and limitations with respect to appetitive cognitive conditioning. However, the CANTAB versions of sustained/divided attention and working memory tasks have to-date not been studied in the marmoset. Here we describe adult marmoset performance on the CANTAB five-choice serial reaction time task, a delayed match-to-position task, and a task derived from the CANTAB visuo-spatial paired associates learning task that constituted two, concurrent delayed match-to-position tasks. The acquisition and stable longitudinal performance of these tasks provide strong evidence that the marmoset, in addition to the macaque, can be the species of choice for CANTAB-based drug and lesion studies of cognitive function, using tasks similar to those deployed in the study of human cognition and diagnosis of neuropsychiatric disorders.
AB - The CAmbridge Neuropsychological Test Automated Battery (CANTAB) is a computerised battery of neuropsychological tests presented as stimuli on a touch-sensitive computer screen that has been used to assess a wide range of cognitive functions in neuropsychiatric patients, healthy volunteers, and species of non-human primate, primarily the rhesus macaque. The common marmoset is a small-bodied, tractable simian primate that breeds well under laboratory conditions. This primate has been quite extensively studied in terms of its abilities and limitations with respect to appetitive cognitive conditioning. However, the CANTAB versions of sustained/divided attention and working memory tasks have to-date not been studied in the marmoset. Here we describe adult marmoset performance on the CANTAB five-choice serial reaction time task, a delayed match-to-position task, and a task derived from the CANTAB visuo-spatial paired associates learning task that constituted two, concurrent delayed match-to-position tasks. The acquisition and stable longitudinal performance of these tasks provide strong evidence that the marmoset, in addition to the macaque, can be the species of choice for CANTAB-based drug and lesion studies of cognitive function, using tasks similar to those deployed in the study of human cognition and diagnosis of neuropsychiatric disorders.
KW - Attention
KW - CANTAB
KW - Learning and memory: systems and functions - animals
KW - Marmoset
KW - Neural Basis of Behavior
KW - Primate
KW - Working memory
UR - http://www.scopus.com/inward/record.url?scp=1542351270&partnerID=8YFLogxK
U2 - 10.1016/j.cogbrainres.2003.11.007
DO - 10.1016/j.cogbrainres.2003.11.007
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AN - SCOPUS:1542351270
SN - 0926-6410
VL - 19
SP - 123
EP - 137
JO - Cognitive Brain Research
JF - Cognitive Brain Research
IS - 2
ER -