Performance of a rapid yeast test in detecting Candida spp. in the vagina

Michael Dan, Yael Leshem, Arie Yeshaya

Research output: Contribution to journalArticlepeer-review

Abstract

We compared the performance of a rapid vaginal yeast assay (Savvycheck) with that of microscopic examination of a Gram-stained smear and culture of vaginal discharge in detecting Candida spp. Two hundred thirty-one women with vaginal symptoms were studied prospectively. Vaginal specimens obtained from all participants were studied by the Savvycheck rapid yeast test, microscopic evaluation of Gram-stained vaginal smears, and yeast culture. Savvycheck rapid yeast test was positive in 79% of women with positive cultures and in 3.6% of women with negative cultures. The Savvycheck test detected yeasts in 93% of subjects with positive Gram stain and in 5.5% of subjects with negative Gram stain. The Savvycheck rapid yeast test showed 93% sensitivity, 95% specificity, and a 97% negative predictive value compared with the Gram stain. It revealed 79% sensitivity, 96% specificity, and an 87% negative predictive value compared with culture. The Savvycheck rapid yeast test can be used in the busy office instead of microscopy as a point-of-care tool for diagnosing vulvovaginal candidiasis. It can also reduce the need for yeast cultures in patients with vaginitis.

Original languageEnglish
Pages (from-to)52-55
Number of pages4
JournalDiagnostic Microbiology and Infectious Disease
Volume67
Issue number1
DOIs
StatePublished - May 2010

Keywords

  • Candida spp.
  • Rapid yeast test
  • Sensitivity and specificity
  • Vulvovaginal candidiasis

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