TY - JOUR
T1 - Percutaneous multielectrode endocardial mapping during ventricular tachycardia in the swine model
AU - Eldar, Michael
AU - Fitzpatrick, Adam P.
AU - Ohad, Dan
AU - Smith, Michael F.
AU - Hsu, Steve
AU - Whayne, James G.
AU - Vered, Zvi
AU - Rotstein, Zeev
AU - Kordis, Thomas
AU - Swanson, David K.
AU - Chin, Michael
AU - Scheinman, Melvin M.
AU - Lesh, Michael D.
AU - Greenspon, Arnold J.
PY - 1996
Y1 - 1996
N2 - Background: Identification of critical areas within the ventricular tachycardia circuit is a prerequisite for catheter ablation. Currently, mapping during ventricular tachycardia, usually performed with standard catheters, is difficult and time-consuming and can be used only in patients with hemodynamically stable tachycardia. Methods and Results: A total of 43 pigs underwent closed chest induction of myocardial infarction. A basket- shaped catheter carrying 64 electrodes was deployed in the left ventricle during normal sinus rhythm. Unipolar pacing at 3 mA was successful in 78% of the basket catheter electrodes, demonstrating good electrode-tissue contact. Hemodynamic and echocardiographic measurements did not reveal any significant interference with myocardial or valvular function during or after catheter deployment. One hundred eighteen episodes of monomorphic ventricular tachycardia were induced in 28 pigs through right ventricular stimulation, 81 of which were mapped and analyzed. Ventricular tachycardia mapping was rapid, requiring only several beats and < 10 seconds to complete. Presystolic potentials, a possible target for ablation, were identified in 58% of the tachycardia episodes mapped. Pathological examination revealed only minor valvular and endocardial catheter-induced lesions immediately after map ping and none a month later. Conclusions: The multielectrode catheter enables rapid and safe percutaneous endocardial mapping of ventricular tachycardia in the swine model. Exploration of the clinical potential of the multielectrode catheter seems warranted.
AB - Background: Identification of critical areas within the ventricular tachycardia circuit is a prerequisite for catheter ablation. Currently, mapping during ventricular tachycardia, usually performed with standard catheters, is difficult and time-consuming and can be used only in patients with hemodynamically stable tachycardia. Methods and Results: A total of 43 pigs underwent closed chest induction of myocardial infarction. A basket- shaped catheter carrying 64 electrodes was deployed in the left ventricle during normal sinus rhythm. Unipolar pacing at 3 mA was successful in 78% of the basket catheter electrodes, demonstrating good electrode-tissue contact. Hemodynamic and echocardiographic measurements did not reveal any significant interference with myocardial or valvular function during or after catheter deployment. One hundred eighteen episodes of monomorphic ventricular tachycardia were induced in 28 pigs through right ventricular stimulation, 81 of which were mapped and analyzed. Ventricular tachycardia mapping was rapid, requiring only several beats and < 10 seconds to complete. Presystolic potentials, a possible target for ablation, were identified in 58% of the tachycardia episodes mapped. Pathological examination revealed only minor valvular and endocardial catheter-induced lesions immediately after map ping and none a month later. Conclusions: The multielectrode catheter enables rapid and safe percutaneous endocardial mapping of ventricular tachycardia in the swine model. Exploration of the clinical potential of the multielectrode catheter seems warranted.
KW - catheter
KW - mapping
KW - tachycardia
UR - http://www.scopus.com/inward/record.url?scp=9544231781&partnerID=8YFLogxK
U2 - 10.1161/01.CIR.94.5.1125
DO - 10.1161/01.CIR.94.5.1125
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AN - SCOPUS:9544231781
SN - 0009-7322
VL - 94
SP - 1125
EP - 1130
JO - Circulation
JF - Circulation
IS - 5
ER -