Percutaneous coronary intervention with ridaforolimus eluting-stents in small vessel coronary artery disease

Ziad Arow, Maayan Konigstein, Hana Vaknin-Assa, Guy Witberg, Michael Jonas, Arthur Kerner, Carlos Cafri, Ronen Rubinshtein, Amit Segev, Ariel Roguin, Melek Ozgu Issever, Mustafa Gabarin, David Pereg, Abid Assali, Edward Koifman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Introduction: The ridaforolimus-eluting stent (RES) system uses a novel cobalt alloy-based coronary stent with a durable elastomeric polymer eluting ridaforolimus. Aim of study: To assess the safety and efficacy of small diameter (2.25 mm) RES (EluNIR) in small coronary artery disease. Methods: A prospective, multicenter, single-arm, open-label clinical trial. Clinical follow-up was performed at 30 days, 6 months, and 1 year after the procedure. Target lesions were located in native coronary arteries or bypass graft conduits, with visually estimated diameter of ≥2.25 mm to ≤2.5 mm. The primary endpoint was combined device success, defined as final in-stent residual diameter stenosis <30%, without 30-day major adverse cardiovascular events (MACE). Results: A total of 81 patients were enrolled in the study. Twenty-three patients (28%) had acute coronary syndrome (ACS) at presentation and 37 (46%) had prior myocardial infarction (MI). Most of the target lesions were located in the circumflex coronary artery (44%) and were classified as B2/C grade according to the American Heart Association/American College of Cardiology classification. The final mean minimal lumen diameter, mean reference vessel diameter, and mean residual percent diameter stenosis were 2.0 ± 0.2 mm, 2.3 ± 0.1 mm, and 14 + 6.6%, respectively. The primary endpoint of device success without 30-day MACE was achieved in 98.8% of the patients. Target lesion failure (TLF) at 6 months was 1.2%. Thirty-day and 1-year MACE rates were 1.2% and 2.5%, respectively. Conclusion: The EluNIR 2.25 mm stent shows excellent results in small coronary artery disease and adds another tool in the treatment of this complex lesion type.

Original languageEnglish
Pages (from-to)61-67
Number of pages7
JournalCatheterization and Cardiovascular Interventions
Issue number1
StatePublished - 1 Jan 2024


  • percutaneous coronary intervention (PCI)
  • ridaforolimus eluting-stents
  • small coronary artery disease


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