Percutaneous coronary intervention in patients with haemophilia presenting with acute coronary syndrome: An interventional dilemma: Case series, review of the literature, and tips for management

Paul Fefer, Sharon Gannot, Aaron Lubetsky, Uri Martinowitz, Shlomi Matetzky, Victor Guetta, Amit Segev

Research output: Contribution to journalReview articlepeer-review

Abstract

Since the introduction of clotting factor concentrates over 50 years ago the life expectancy of patients with hemophilia (PWH) has increased to over 70 years. Consequently, diseases of the ageing population, including coronary artery disease, are increasingly being encountered. These patients present a unique therapeutic problem due to their greatly increased bleeding risk. Randomized controlled studies specific to PWH are lacking, emphasizing the need for case series. We present three cases of acute coronary syndrome in PWH who underwent urgent percutaneous coronary intervention at our institution, and summarize the available literature on the topic. We describe their management and outcome and provide points to consider when treating these complex patients.

Original languageEnglish
Pages (from-to)271-278
Number of pages8
JournalJournal of Thrombosis and Thrombolysis
Volume35
Issue number2
DOIs
StatePublished - Feb 2013

Keywords

  • Acute coronary syndrome
  • Anti-platelets
  • Anticoagulation
  • Coagulation factors
  • Haemophilia
  • Percutaneous coronary angioplasty

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