Percutaneous absorption of alkanoic acids II: Application of regular solution theory

Zvi Liron, Sasson Cohen

Research output: Contribution to journalArticlepeer-review

Abstract

The permeability coefficient, Kp, of pure unbranched alkanoic acids (C2‐C7) applied to isolated porcine skin, reached a maximum in the solubility parameter (δ2) range of 9.7–10 cal1/2/cm3/2. When these and other penetrants were delivered from a solvent vehicle, the following linear relationships could be demonstrated: (a) between log Kp and the molar attraction constant of the penetrant [δ2v2 or (‐Ev)1/2] for six unbranched and six branched acids delivered from 1 M solution in n‐heptane; (b) between Kp and the partial molal volume difference in n‐heptane (ν2 ‐ v 20) for the unbranched acids; and (c) between Kp and (ν2 ‐ v 20) for propionic acid delivered from 1 M solutions in nine solvents having δ1 values in the range 7.4–12.7 cal1/2/cm3/2. Drug penetrability in a given series could be assessed from knowledge of the excess free energy of the penetrant in the delivery system used.

Original languageEnglish
Pages (from-to)538-542
Number of pages5
JournalJournal of Pharmaceutical Sciences
Volume73
Issue number4
DOIs
StatePublished - Apr 1984

Keywords

  • Absorption, percutaneous—alkanoic acids in vitro, porcine skin, permeability coefficients, application of regular solution theory
  • Alkanoic acids—percutaneous absorption in vitro, porcine skin, permeability coefficients, application of regular solution theory
  • Permeability coefficients—alkanoic acids through porcine skin, in vitro percutaneous absorption, application of regular solution theory

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