TY - JOUR
T1 - Percutaneous absorption of alkanoic acids I
T2 - A study of operational conditions
AU - Liron, Zvi
AU - Cohen, Sasson
N1 - Funding Information:
Center by Grant No. HL19127 awarded by the Heart, Lung and Blood Institute, at the Armed Forces Radiobiology Research Institute by Research Work Unit 7452-00056 and 7452-00084, and by Grant No. ER60039 awarded by the Department of Energy. We appreciate the technical assistance of Mr. Ralph Will at GWU and E. Barron, N. Fleming, M. Flynn, J. Josza, J. Warrenfeltz, and M. Corral of the AFRRI. Animal research at AFRRI was conducted according to the principles enunciated in the “Guide for the Care and Use of Laboratory Animals,” prepared by the Institute of Laboratory Animal Resources, National Research Council.
PY - 1984/4
Y1 - 1984/4
N2 - The rate of penetration of propionic and butyric acids through excised porcine skin was determined in vitro in specific apparatus allowing optimal control of operational conditions. In one technique, the rate was followed by continuous pH‐stat titration of acid appearing in the perfusate, in another, by periodic monitoring of [14C]propionic acid in the perfusate. With the assumption that Fick's equation applies to the process of penetration, it was found that the permeability coefficient, Kp, increases with increasing mass of neat penetrant applied per unit area to the donor side, increases with increasing concentration of penetrant in n‐heptane as vehicle, increases with increasing temperature, Ea =11.4 kcal/mol, and decreases with decreasing perfusion rate of the acceptor side when this rate is smaller than 60 mL/h.
AB - The rate of penetration of propionic and butyric acids through excised porcine skin was determined in vitro in specific apparatus allowing optimal control of operational conditions. In one technique, the rate was followed by continuous pH‐stat titration of acid appearing in the perfusate, in another, by periodic monitoring of [14C]propionic acid in the perfusate. With the assumption that Fick's equation applies to the process of penetration, it was found that the permeability coefficient, Kp, increases with increasing mass of neat penetrant applied per unit area to the donor side, increases with increasing concentration of penetrant in n‐heptane as vehicle, increases with increasing temperature, Ea =11.4 kcal/mol, and decreases with decreasing perfusion rate of the acceptor side when this rate is smaller than 60 mL/h.
KW - Absorption, percutaneous—alkanoic acids in vitro, porcine skin, permeability coefficients, operational conditions
KW - Alkanoic acids—percutaneous absorption in vitro, porcine skin, permeability coefficients, operational conditions
KW - Permeability coefficients—alkanoic acids through porcine skin, in vitro percutaneous absorption, operational conditions
UR - http://www.scopus.com/inward/record.url?scp=0021234780&partnerID=8YFLogxK
U2 - 10.1002/jps.2600730425
DO - 10.1002/jps.2600730425
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:0021234780
SN - 0022-3549
VL - 73
SP - 534
EP - 537
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
IS - 4
ER -