Peptide Nanophotonics: From Optical Waveguiding to Precise Medicine and Multifunctional Biochips

Boris Apter, Nadezda Lapshina, Amir Handelman, Boris D. Fainberg, Gil Rosenman

Research output: Contribution to journalReview articlepeer-review


Optical waveguiding phenomena found in bioinspired chemically synthesized peptide nanostructures are a new paradigm which can revolutionize emerging fields of precise medicine and health monitoring. A unique combination of their intrinsic biocompatibility with remarkable multifunctional optical properties and developed nanotechnology of large peptide wafers makes them highly promising for new biomedical light therapy tools and implantable optical biochips. This Review highlights a new field of peptide nanophotonics. It covers peptide nanotechnology and the fabrication process of peptide integrated optical circuits, basic studies of linear and nonlinear optical phenomena in biological and bioinspired nanostructures, and their passive and active optical waveguiding. It is shown that the optical properties of this generation of bio-optical materials are governed by fundamental biological processes. Refolding the peptide secondary structure is followed by wideband optical absorption and visible tunable fluorescence. In peptide optical waveguides, such a bio-optical effect leads to switching from passive waveguiding mode in native α-helical phase to an active one in the β-sheet phase. The found active waveguiding effect in β-sheet fiber structures below optical diffraction limit opens an avenue for the future development of new bionanophotonics in ultrathin peptide/protein fibrillar structures toward advanced biomedical nanotechnology.

Original languageEnglish
Article number1801147
Issue number34
StatePublished - 23 Aug 2018


  • beta-sheet visible fluorescence
  • implantable biochips
  • nonlinear optical and electrooptical effects
  • passive and active optical waveguides
  • peptide nanophotonics
  • reconformation of peptide secondary structure
  • switching of waveguiding regimes


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