@inproceedings{49d3202209544d86bf0317b24ed7864e,
title = "PepCrawler: A fast RRT-like algorithm for high-resolution refinement and binding-affinity estimation of peptide inhibitors",
abstract = "Design of protein-protein interaction (PPI) inhibitors is a key challenge in Structural Bioinformatics and Computer Aided Drug Design [1, 2]. Peptides, which partially mimic the interface area of one of the interacting proteins, are natural candidates to form protein-peptide complexes competing with the original PPI [3, 4]. Some inhibitory peptides were designed by deriving a short linear segment from one of the proteins in a given PPI complex [5-9]. These peptides were successfully able to inhibit interactions with the partner protein. The prediction of such complexes is especially challenging due to the high flexibility of peptide conformations.",
keywords = "PepCrawler, RRT, derived peptides, peptide inhibitors, protein-peptide docking, protein-protein interactions",
author = "Elad Donsky and Wolfson, {Haim J.}",
year = "2011",
doi = "10.1007/978-3-642-23038-7_7",
language = "אנגלית",
isbn = "9783642230370",
series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
pages = "73--75",
booktitle = "Algorithms in Bioinformatics - 11th International Workshop, WABI 2011, Proceedings",
note = "null ; Conference date: 05-09-2011 Through 07-09-2011",
}