Pentagastrin protects the proximal small intestine against indomethacin-induced ulcers in the rat

Leora Harel; Ilan Zahavi; Hedva Marcus; Yehezkel Waisman; Moshe Ligumsky; Yoram Rosenbach; Gabriel Dinari

doi:10.1159/000199585

Pentagastrin protects the proximal small intestine against indomethacin-induced ulcers in the rat

Leora Harel, Ilan Zahavi, Hedva Marcus, Yehezkel Waisman, Moshe Ligumsky, Yoram Rosenbach, Gabriel Dinari^*

^*Corresponding author for this work

Clinical Departments

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6 Scopus citations

Abstract

The possible protective effects of pentagastrin on indomethacin-induced small intestinal ulceration were investigated in rats. Ulcers were induced by subcutaneous injection of 30 mg/kg indomethacin, 30 min after refeeding rats fasted for 24 h. Administration of pentagastrin at a dose of 250 or 400 μg/kg i.p., 3 h prior to refeeding, reduced total ulcer area from 27.6 ± 6.5 to 7.2 ± 1.97 mm2 (mean ± SEM; p < 0.02) in the proximal small intestine only. Cyclic adenosine monophasphate, but not prostaglandin E₂levels were significantly raised by 250 μg/kg pentagastrin (0.15 ± 0.05 vs. 0.38 ± 0.07 pmol/mg protein; mean ± SEM; p < 0.02) in the same intestinal segment.

Original language	English
Pages (from-to)	156-159
Number of pages	4
Journal	Digestion
Volume	38
Issue number	3
DOIs	https://doi.org/10.1159/000199585
State	Published - 1987

Keywords

Gastrin
Indomethacin
Mucosal protection
Small intestine
Ulcers

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10.1159/000199585

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title = "Pentagastrin protects the proximal small intestine against indomethacin-induced ulcers in the rat",

abstract = "The possible protective effects of pentagastrin on indomethacin-induced small intestinal ulceration were investigated in rats. Ulcers were induced by subcutaneous injection of 30 mg/kg indomethacin, 30 min after refeeding rats fasted for 24 h. Administration of pentagastrin at a dose of 250 or 400 μg/kg i.p., 3 h prior to refeeding, reduced total ulcer area from 27.6 ± 6.5 to 7.2 ± 1.97 mm2 (mean ± SEM; p < 0.02) in the proximal small intestine only. Cyclic adenosine monophasphate, but not prostaglandin E2levels were significantly raised by 250 μg/kg pentagastrin (0.15 ± 0.05 vs. 0.38 ± 0.07 pmol/mg protein; mean ± SEM; p < 0.02) in the same intestinal segment.",

keywords = "Gastrin, Indomethacin, Mucosal protection, Small intestine, Ulcers",

author = "Leora Harel and Ilan Zahavi and Hedva Marcus and Yehezkel Waisman and Moshe Ligumsky and Yoram Rosenbach and Gabriel Dinari",

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AU - Harel, Leora

AU - Zahavi, Ilan

AU - Marcus, Hedva

AU - Waisman, Yehezkel

AU - Ligumsky, Moshe

AU - Rosenbach, Yoram

AU - Dinari, Gabriel

PY - 1987

Y1 - 1987

N2 - The possible protective effects of pentagastrin on indomethacin-induced small intestinal ulceration were investigated in rats. Ulcers were induced by subcutaneous injection of 30 mg/kg indomethacin, 30 min after refeeding rats fasted for 24 h. Administration of pentagastrin at a dose of 250 or 400 μg/kg i.p., 3 h prior to refeeding, reduced total ulcer area from 27.6 ± 6.5 to 7.2 ± 1.97 mm2 (mean ± SEM; p < 0.02) in the proximal small intestine only. Cyclic adenosine monophasphate, but not prostaglandin E2levels were significantly raised by 250 μg/kg pentagastrin (0.15 ± 0.05 vs. 0.38 ± 0.07 pmol/mg protein; mean ± SEM; p < 0.02) in the same intestinal segment.

AB - The possible protective effects of pentagastrin on indomethacin-induced small intestinal ulceration were investigated in rats. Ulcers were induced by subcutaneous injection of 30 mg/kg indomethacin, 30 min after refeeding rats fasted for 24 h. Administration of pentagastrin at a dose of 250 or 400 μg/kg i.p., 3 h prior to refeeding, reduced total ulcer area from 27.6 ± 6.5 to 7.2 ± 1.97 mm2 (mean ± SEM; p < 0.02) in the proximal small intestine only. Cyclic adenosine monophasphate, but not prostaglandin E2levels were significantly raised by 250 μg/kg pentagastrin (0.15 ± 0.05 vs. 0.38 ± 0.07 pmol/mg protein; mean ± SEM; p < 0.02) in the same intestinal segment.

KW - Gastrin

KW - Indomethacin

KW - Mucosal protection

KW - Small intestine

KW - Ulcers

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Pentagastrin protects the proximal small intestine against indomethacin-induced ulcers in the rat

Abstract

Keywords

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