Penetration of selected Dead Sea minerals through a healthy rabbit skin, from a sustained-release transparent varnish, as a prospective treatment for psoriasis

Jashovam Shani, Ahmed Sulliman, Itzhak Katzir, Sarah Brenner

Research output: Contribution to journalArticlepeer-review

Abstract

Bathing in the Dead Sea is an established treatment for psoriasis. Penetration of Dead Sea minerals into psoriatic skin is an effective factor in this treatment, but applying it clinically requires frequent bathing in the Dead Sea or in its bath-salt solution. We tested an ethyl-cellulose-based transparent varnish with a sustained-release property, for its penetrability of such minerals. Minerals tested were MgBr2 and KBr, known for their relevance in psoriatic proliferation. They were applied for up to three weeks. We could demonstrate that two weekly applications of the salt-containing varnish on healthy rabbit skin are enough to obtain elevated levels of magnesium and potassium in their plasma. We propose the application of Dead Sea minerals containing varnish as a clinical treatment for psoriasis.

Original languageEnglish
Pages (from-to)267-272
Number of pages6
JournalJournal of the European Academy of Dermatology and Venereology
Volume4
Issue number3
DOIs
StatePublished - Jun 1995
Externally publishedYes

Keywords

  • Dead Sea minerals
  • Psoriasis
  • Sustained release transparent varnish

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